3 papers1 finding
Frailty
downin humans1
Frailty is associated with mitochondrial respiratory capacity in humans.
“Frail older adults exhibit reduced mitochondrial DNA content, diminished mitochondrial respiratory capacity, elevated reactive oxygen species generation, and distinctive metabolomic changes.”
Reviewin older adults
The mitochondrial side of frailty
Current opinion in clinical nutrition and metabolic care3 Oct 2025
Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.
In an experiment in mice with features of premature aging, a compound improved the performance of mitochondria, the energy-producing structures in muscle cells.In an experiment in mice with features of premature aging, a compound improved the performance of mitochondria, the energy-producing structures in muscle cells.
Aged mice on a high-fat diet and L-NAME showed impaired mitochondrial proteostasis rather than defective biogenesis, suggesting quality control may contribute to reduced…Aged mice on a high-fat diet and L-NAME showed impaired mitochondrial proteostasis rather than defective biogenesis, suggesting quality control may contribute to reduced cardiac reserve.