An observational study of healthy volunteers aged 9 months to 65 years found the most pronounced immune-cell shifts at ages 10–19, with different patterns by sex.An observational study of healthy volunteers aged 9 months to 65 years found the most pronounced immune-cell shifts at ages 10–19, with different patterns by sex.
Cross-sectional study of 1,796 healthy volunteers of both sexesImmune response
Limit: Unadjusted lifetime infectious/parasitic exposures could explain some apparent age-linked remodeling
Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signalling.Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signalling.
Experiments in male and female mice with differing mtDNA, against mice with C57 mtDNAMitochondrion
Limit: The mtDNA damage result lost significance when a potential outlier was excluded
Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.Mice carrying one copy of a progeria-linked mutation developed increased gut leakage from 30 weeks, reaching levels reported in naturally aged mice over 20 months old.
Preprint: experiments in heterozygous progeria miceLMNA
Limit: The link between mitochondrial dysfunction and impaired cell maturation remains a proposed model
Only one pair shared the immune-blocking proteins while 35 pairs differed, with autoantibodies detected in 1.5% of the 3,270 older twins tested.Only one pair shared the immune-blocking proteins while 35 pairs differed, with autoantibodies detected in 1.5% of the 3,270 older twins tested.
Experiments with adult human lung cells produced cells that could multiply extensively and form three-dimensional models resembling mature lung air sacs.Experiments with adult human lung cells produced cells that could multiply extensively and form three-dimensional models resembling mature lung air sacs.