4 papers2 findings
Caloric restriction
downin mice1
Caloric restriction prevents myeloid leukemia in mice.
“there was a significant difference in the prevention of myeloid leukemogenesis”
Animalsradiation-inducedspleen
Experimental hematology1 Mar 2006
Caloric restriction
downin mice1
Caloric restriction lowers the risk of myeloid leukemia in mice (7.9% vs 23.3%).
“reduced to 7.9% and 10.7% when restriction was started before (6 weeks old) and after (10 weeks old) irradiation, respectively.”
Animalsin mice given 3 Gy whole-body x-ray irradiation, started before irradiation (6 weeks old)males
Proceedings of the National Academy of Sciences of the United States of America18 Mar 1997
Company1 trialPhase 2/3306 people
Novartis Pharmaceuticals Corporation
Company1 trialPhase 1241 people
Company1 trialPhase 1170 people
Company1 trialPhase 11 person
1 trialPhase 358 people
1 trialPhase 2/3550 people
1 trialPhase 2100 people
Children's Hospital of Philadelphia
1 trialPhase 280 people
VetenskapsrådetSEK 4.8mJapan Society for the Promotion of ScienceJP¥4m
Japan Society for the Promotion of ScienceInternational University of Health and WelfareJP¥4m2019–2025
VetenskapsrådetUppsala UniversitySEK 4.8m2019–2022
People starting nilotinib, a leukaemia drug, had a hazard ratio of 0.37 for neurodegenerative disease diagnosis or death versus matched people without chronic myeloid…People starting nilotinib, a leukaemia drug, had a hazard ratio of 0.37 for neurodegenerative disease diagnosis or death versus matched people without chronic myeloid leukaemia.
The method paired gene activity and DNA-marking measurements at about 10,000 cells per sequencing library, a collection of prepared genetic material.The method paired gene activity and DNA-marking measurements at about 10,000 cells per sequencing library, a collection of prepared genetic material.
Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.