Hematologic malignancy
Disease2 papers1 finding
- In silico1
Associations
1Clonal hematopoiesis of indeterminate potential
upin humans1
1 study
Clonal hematopoiesis of indeterminate potential
upin humans1
Clonal hematopoiesis of indeterminate potential raises the risk of hematologic malignancy in humans.
Reviewspecific clonal hematopoiesis-associated mutations and clonal features
Clinical management of clonal hematopoiesis · Cancer · 14 Sep 2026
Trial sponsors
Company1 trialPhase 31,718 people
Company1 trialPhase 260 people
Company1 trialPhase 115 people
Company1 trialPhase 112 people
2 trialsPhase 2160 people
National Heart, Lung, and Blood Institute
1 trialPhase 250 people
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
1 trialPhase 225 people
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
1 trialPhase 1/287 people
Latest
20TET deficiency drives selection of aneuploid cells in mice
In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during…In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular expansion.
ASXL1 clonal hematopoiesis is linked to lung cancer risk
In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among…In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among ever-smokers.
Raising H3K9 methylation curbs leukemogenesis in mice
Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.