Cytotoxicity

Biomarker

3 papers

Model organisms1
Cells2

Funding

1 grant since 2017

Japan Society for the Promotion of ScienceJP¥4.6m

Differential cytotoxicity induced by statins in inflammatory mileaus
Japan Society for the Promotion of ScienceTeikyo UniversityJP¥4.6m2017–2023

Latest

223 in 12 months

Research Square7 h

Vaccine patch under the tongue protected aged mice from flu

When aged mice were exposed to influenza, the patch provided 100% protection, compared with 75–80% protection from injected formulations.When aged mice were exposed to influenza, the patch provided 100% protection, compared with 75–80% protection from injected formulations.

Preprint: experiments in young and aged mice, against aged mice receiving an injected boostInterventions

Limit: Protection was measured after injected priming, not with the patch alone

Paper

Research Square7 h

Riociguat Suppresses Osteoclastogenesis and Ovariectomy-Induced Bone Loss by Attenuating MAPK Signaling and PPARγ–PGC-1β Coupling

Preprint: experiments in miceBone loss

Paper

Acta Orthopaedica Belgica12 h

3D bioprinted porous PLLA implants with dual gene modified BMSCs for osteoarthritis cartilage repair

Experiments in animalsOsteoarthritis

Paper

Frontiers in OncologyYesterday

Silent, but not innocent: the emerging role of clonal hematopoiesis in predicting therapy-related myeloid neoplasms

ReviewBlood and immune system

Paper

NPJ Regenerative MedicineYesterday

Some immune cells hindered digit-tip regrowth in mice

Cell-transfer experiments in mice lacking lymphoid immune cells found that regulatory immune cells rescued regeneration inhibited by another immune-cell type.Cell-transfer experiments in mice lacking lymphoid immune cells found that regulatory immune cells rescued regeneration inhibited by another immune-cell type.

Experiments in lymphoid-deficient mutant mice, against mice receiving CD8 T cellsImmune response

Limit: The experiments did not assess how aging affects digit-tip regeneration

Paper

Free Radical Biology & Medicine14 Oct

A protease-resistant D-amino acid αA-crystallin mini-chaperone with enhanced chaperone and antioxidant activities protects against amyloid-β proteotoxicity

Experiments in wormsInterventions

Paper

Biotechnic & Histochemistry9 Oct

Micronucleus cytome assay reveals genomic instability in premalignant cervical lesions among high-risk HPV-positive women

Cross-sectional study of 184 peopleBiomarkers

Paper

bioRxiv9 Oct

Age-associated transcriptional programs in tumor-associated macrophages are associated with tumor progression in HPV-negative oral cancer

Preprint: computational studyInflammation

Paper

Journal of Biochemical and Molecular Toxicology7 Oct

Diesel-derived chemical triggers scarring signals in kidney cells

Experiments in kidney cells grown in the lab found that a diesel exhaust breakdown product caused lasting DNA damage and signals that activated connective-tissue cells.Experiments in kidney cells grown in the lab found that a diesel exhaust breakdown product caused lasting DNA damage and signals that activated connective-tissue cells.

Experiments in cellsKidney

Paper

Frontiers in Pharmacology2 Oct

Melissic acid reduces senescence in human stem cells via cAMP signaling

A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.

Experiments in human cellsInterventions

Paper

Cytotoxicity

Funding

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