The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to…The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions. In a preprint analyzing data from thousands of human adults, researchers built and tested a mechanistic biological age…
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult…A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts. In a preprint analyzing 3,642 older Americans and 18,676 Scottish adults, researchers evaluated whether a DNA-methylation index of…
A machine-learning model trained on gerbil synapse counts separated age groups above chance when tested on 56 human listeners.A machine-learning model trained on gerbil synapse counts separated age groups above chance when tested on 56 human listeners. In Mongolian gerbils with histologically verified cochlear neural degeneration, researchers evaluated dynamic amplitude-modulated envelope following responses that…
A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand…A new computational tool links cellular maintenance modules to tissue-specific age patterns across two human cohorts totaling over two thousand participants. In a preprint, researchers analyzed blood DNA-methylation profiles from 656 discovery and 1,394 replication human participants to…
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from…Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality. In a preprint analyzing 409,206 human participants from the UK Biobank, researchers built multi-omics clocks to measure the aging…
In older men, a five-variable physical model beat FRAX without bone scans, raising 10-year fracture discrimination by an area under the curve of…In older men, a five-variable physical model beat FRAX without bone scans, raising 10-year fracture discrimination by an area under the curve of 0.052. In community-dwelling older men and women, researchers evaluated whether an imaging-free model based on physical performance could predict…
In nearly 600,000 individuals, multi-ancestry fine-mapping resolved 521 causal signals for type 2 diabetes, with 74% shared between East Asian and…In nearly 600,000 individuals, multi-ancestry fine-mapping resolved 521 causal signals for type 2 diabetes, with 74% shared between East Asian and European ancestries. In a study of 596,778 individuals of East Asian ancestry, researchers evaluated the genetic architecture of type 2…
In 1,505,638 COPD patients, high frailty was linked to mortality hazard ratios of 2.66 under age 70 and 1.90 at 70 and older versus low-frailty older…In 1,505,638 COPD patients, high frailty was linked to mortality hazard ratios of 2.66 under age 70 and 1.90 at 70 and older versus low-frailty older peers. In a nationwide retrospective cohort of 1,505,638 South Korean patients aged 40 and older with chronic obstructive pulmonary disease…
In over 1.8 million Japanese adults, the highest quartile of estimated sdLDL-C carried an ASCVD hazard ratio of 1.25 compared with the lowest.In over 1.8 million Japanese adults, the highest quartile of estimated sdLDL-C carried an ASCVD hazard ratio of 1.25 compared with the lowest. In a study of 1,884,758 Japanese adults aged 40 to 74 years, higher estimated small dense low-density lipoprotein cholesterol was associated with…
A high biomarker score carried nearly threefold greater atrial fibrillation risk than a very low score (HR 2.72; 95% CI, 2.11-3.49).A high biomarker score carried nearly threefold greater atrial fibrillation risk than a very low score (HR 2.72; 95% CI, 2.11-3.49). In a study of 6,429 Multi-Ethnic Study of Atherosclerosis participants initially free of atrial fibrillation and clinical cardiovascular disease, researchers…
Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival.Data from NHANES and the UK Biobank show phenotypic and biological age measures track with gout incidence and subsequent survival. In human participants from the National Health and Nutrition Examination Survey (NHANES) and the UK Biobank, researchers examined whether biological age tracks…
Researchers analyzed serial electrocardiograms from over 128,000 patients to distinguish cumulative cardiac aging damage from the rate of future…Researchers analyzed serial electrocardiograms from over 128,000 patients to distinguish cumulative cardiac aging damage from the rate of future electrical changes. In an observational study of 128,605 human patients, researchers analyzed 399,786 standard 12-lead electrocardiograms to…
In 1,295 patients, normalized upper cervical cord area dropped below healthy control levels starting at age 30, diverging most in the fifth and sixth…In 1,295 patients, normalized upper cervical cord area dropped below healthy control levels starting at age 30, diverging most in the fifth and sixth decades. In a cross-sectional study of 1,295 patients with multiple sclerosis and 480 healthy controls aged 18 to 70 years, researchers…
In 2,928 individuals across five Latin American countries, speech age gaps tracked dementia diagnoses, brain age, social exposome, and epigenetic…In 2,928 individuals across five Latin American countries, speech age gaps tracked dementia diagnoses, brain age, social exposome, and epigenetic aging clocks. In a cross-sectional study of 2,928 human participants across five Latin American countries, researchers developed a speech-based…
In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk…In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14). In older human adults from the UK Biobank and the Atherosclerosis Risk in Communities study, researchers evaluated whether…
In 710 older adults, delayed recall linguistic scores predicted cognitive impairment with an AUC-PR of 0.77, compared with 0.81 for traditional…In 710 older adults, delayed recall linguistic scores predicted cognitive impairment with an AUC-PR of 0.77, compared with 0.81 for traditional scoring. In 710 older adults from the Long Life Family Study, researchers analyzed digital voice recordings from logical memory tests.
In 10,550 young adults followed for 22.7 years, elevated Martin-Hopkins LDL-C yielded a hazard ratio of 1.69 for cardiovascular events versus 1.47 for…In 10,550 young adults followed for 22.7 years, elevated Martin-Hopkins LDL-C yielded a hazard ratio of 1.69 for cardiovascular events versus 1.47 for the Friedewald equation.
