In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status…In cognitively unimpaired older adults, intermediate amyloid burden showed lower dopamine-transporter deviation scores than amyloid-positive status, with an adjusted difference of −0.582.
Researchers show that standard age-trained clocks reflect task-specific statistics rather than true biological aging constructs, limiting how…Researchers show that standard age-trained clocks reflect task-specific statistics rather than true biological aging constructs, limiting how researchers interpret clock gaps and rejuvenation.
Researchers used transcriptomic models, DNA methylation, and images across multiple human cohorts to infer tissue-specific biological age and hallmark…Researchers used transcriptomic models, DNA methylation, and images across multiple human cohorts to infer tissue-specific biological age and hallmark burdens. In a preprint analyzing human datasets, researchers developed transcriptomic clocks to infer organ biological age and cellular…
Researchers evaluated three multimodal AI models and 92 physicians classifying 90 lumbar scans against dual-energy X-ray absorptiometry T-score…Researchers evaluated three multimodal AI models and 92 physicians classifying 90 lumbar scans against dual-energy X-ray absorptiometry T-score thresholds. In human imaging scans, researchers tested whether multimodal generative artificial intelligence models could screen for osteoporosis…
Penalized regression achieved an AUROC of 0.728 for dual vulnerability and 0.755 for death, against 0.629 for catastrophic health spending alone.Penalized regression achieved an AUROC of 0.728 for dual vulnerability and 0.755 for death, against 0.629 for catastrophic health spending alone. In older Chinese adults, researchers evaluated transitions between functional impairment, catastrophic health spending, and death.
In the UK Biobank, participants with high AIP and low eGDR had a hazard ratio of 5.24 for multimorbidity compared with the low-AIP and high-eGDR…In the UK Biobank, participants with high AIP and low eGDR had a hazard ratio of 5.24 for multimorbidity compared with the low-AIP and high-eGDR group. In a prospective study analyzing 394,483 UK Biobank participants and 8,671 participants from the China Health and Retirement Longitudinal…
In 2,397 postmenopausal women, sleep disorder prevalence reached 62.4%, with depressive status showing the strongest association at an odds ratio of…In 2,397 postmenopausal women, sleep disorder prevalence reached 62.4%, with depressive status showing the strongest association at an odds ratio of 4.067. In a cross-sectional study of 2,397 naturally postmenopausal women aged 45 to 60 years from China, researchers evaluated machine…
An exposome-based model reached an AUC of 0.718 for incident dementia, outperforming demographics and APOE status alone at 0.678 over 15.3 years of…An exposome-based model reached an AUC of 0.718 for incident dementia, outperforming demographics and APOE status alone at 0.678 over 15.3 years of follow-up. Researchers analyzed 499,992 UK Biobank participants aged 40 to 69 to evaluate how 193 environmental factors across five domains…
In 4,543 adults, each standard deviation drop in amidation enzyme activity raised incident Alzheimer's risk with an adjusted hazard ratio of 2.30.In 4,543 adults, each standard deviation drop in amidation enzyme activity raised incident Alzheimer's risk with an adjusted hazard ratio of 2.30. In 4,543 dementia-free adults from the Swedish Malmö Preventive Project, researchers tracked incident dementia over an average follow-up of…
In a study of 324,806 ICU admissions, lower arterial blood pH within 24 hours showed a stronger link to mortality in patients aged 65 and older.In a study of 324,806 ICU admissions, lower arterial blood pH within 24 hours showed a stronger link to mortality in patients aged 65 and older. In a nationwide retrospective study of 324,806 adult intensive care unit admissions in Japan, researchers examined whether patient age influences…
A baseline deep learning score above 0.5 was associated with a 13.41% relative annual fibrosis increase and higher mortality in two human cohorts.A baseline deep learning score above 0.5 was associated with a 13.41% relative annual fibrosis increase and higher mortality in two human cohorts. In human participants without clinically diagnosed interstitial lung disease, automated CT scan analysis identified individuals at elevated…
An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated…An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres. Researchers studied 80 community-dwelling older adults in Santiago, Chile, using data from the ALEXANDROS cohort.
In 3,038 adults with chronic kidney disease followed for 8.5 years, each one-point drop in physical performance score was tied to higher mortality and…In 3,038 adults with chronic kidney disease followed for 8.5 years, each one-point drop in physical performance score was tied to higher mortality and heart failure risk. In a study of 3,038 adults with chronic kidney disease, researchers evaluated lower-extremity physical function and…
In 59,416 UK Biobank participants, peak early diastolic longitudinal strain rate showed the strongest association with incident heart failure, with a…In 59,416 UK Biobank participants, peak early diastolic longitudinal strain rate showed the strongest association with incident heart failure, with a hazard ratio of 0.55. In a cohort of 59,416 UK Biobank participants with a mean age of 65.4 years, researchers evaluated whether cardiac MRI…
Epigenetic telomere length analysis in patients with sclerosing or biliary cholangitis reveals converging markers of accelerated biological aging.Epigenetic telomere length analysis in patients with sclerosing or biliary cholangitis reveals converging markers of accelerated biological aging. In a human observational study, researchers evaluated DNA methylation-derived telomere length in 474 patients with primary sclerosing…
Across 46,836 adults, each standard deviation increase in retinal nerve fiber layer asymmetry was linked to hazard ratios from ~1.07 for atrial…Across 46,836 adults, each standard deviation increase in retinal nerve fiber layer asymmetry was linked to hazard ratios from ~1.07 for atrial fibrillation to 1.15 for heart failure.
In an analysis of 1,324 cases and 42,065 noncases, 143 DNA methylation sites showed putative causal links to incident abdominal aortic aneurysm.In an analysis of 1,324 cases and 42,065 noncases, 143 DNA methylation sites showed putative causal links to incident abdominal aortic aneurysm. In human participants from the Veterans Affairs Million Veteran Program, researchers conducted an epigenome-wide association study of incident…
Baseline TyG-CVAI predicted follow-up frailty index with a standardized β of 0.165, compared with a standardized β of 0.035 for the reverse path.Baseline TyG-CVAI predicted follow-up frailty index with a standardized β of 0.165, compared with a standardized β of 0.035 for the reverse path. In 2,476 participants from the China Multi-Ethnic Cohort study in southwestern China, researchers examined the bidirectional relationship…
