Whole body
Body system466 papersUBERON 0000468
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- Humans277
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Latest
466Combined frailty and metabolic index tracks multimorbidity risk
Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic…Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic multimorbidity.
Early cognitive frailty can reverse in rural older adults
In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical…In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical frailty, versus 0.224 toward further deterioration.
Sex, Racial/Ethnic, and Regional Disparities in Mortality Involving Both Cardiac Arrest and Type 2 Diabetes Mellitus Among U.S. Adults, 1999-2020
Metabolic signature links frailty to coronary artery disease
A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year…A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year follow-up.
Statins are associated with decreased risk of disease progression and death in non-cirrhotic patients with primary biliary cholangitis
TMEM174 deficiency shortens lifespan and stiffens vessels in mice
Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification…Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality.
Brain signatures of BMI detect systemic disease better than BMI
Across six human cohorts and a 2.3-year follow-up, neural networks identified brain structural patterns tied to cardiometabolic and pulmonary…Across six human cohorts and a 2.3-year follow-up, neural networks identified brain structural patterns tied to cardiometabolic and pulmonary conditions.
Most COPD is underdiagnosed and linked to higher mortality
In over 119,000 adults, 89.2% of COPD cases were underdiagnosed, which was associated with a 1.53 hazard ratio for mortality compared to having no…In over 119,000 adults, 89.2% of COPD cases were underdiagnosed, which was associated with a 1.53 hazard ratio for mortality compared to having no COPD.
Electronic frailty index predicts CAR-T outcomes in older adults
Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.
Calcium overload impairs muscle regeneration by driving sustained NFAT signaling
Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.Inhibiting NFAT restored myoblast differentiation in culture and improved myofiber repair in injured mice.