Caenorhabditis elegans

1. Gracilariopsis lemaneiformis polysaccharides extend lifespan in worms.

   “Lifespan extension also persisted in a daf-16 loss-of-function background, supporting contributions from complementary longevity networks.”

   Model organismsin a daf-16 loss-of-function background

   Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions · Foods (Basel, Switzerland) · 16 Sep 2026

2. Gracilariopsis lemaneiformis polysaccharides decrease malondialdehyde in worms (-73.4%).

   “redox homeostasis (SOD activity +19.5%, MDA content -73.4% for GP-H)”

   Model organismsin wild-type N2 wormsfermented with Lactiplantibacillus plantarum HJ-S2

   Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions · Foods (Basel, Switzerland) · 16 Sep 2026

3. Gracilariopsis lemaneiformis polysaccharides increase superoxide dismutase in worms (+19.5%).

   “redox homeostasis (SOD activity +19.5%, MDA content -73.4% for GP-H)”

   Model organismsin wild-type N2 wormsfermented with Lactiplantibacillus plantarum HJ-S2

   Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions · Foods (Basel, Switzerland) · 16 Sep 2026

4. Gracilariopsis lemaneiformis polysaccharides improve locomotion in worms.

   “improved heat and oxidative stress survival (median survival +44% and +20% for GP-H, respectively), locomotion, redox homeostasis”

   Model organismsin wild-type N2 worms

   Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions · Foods (Basel, Switzerland) · 16 Sep 2026

5. Gracilariopsis lemaneiformis polysaccharides extend lifespan in worms (+21.21% mean lifespan).

   “In wild-type N2 worms, GP, GP-D, and GP-H extended mean lifespan by 8.61%, 14.70%, and 21.21%, respectively”

   Model organismsin wild-type N2 wormsfermented with Lactiplantibacillus plantarum HJ-S2

   Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions · Foods (Basel, Switzerland) · 16 Sep 2026

6. Gracilariopsis lemaneiformis polysaccharides extend lifespan in worms (+14.70% mean lifespan).

   “In wild-type N2 worms, GP, GP-D, and GP-H extended mean lifespan by 8.61%, 14.70%, and 21.21%, respectively”

   Model organismsin wild-type N2 wormsfermented with Lacticaseibacillus casei DS31

   Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions · Foods (Basel, Switzerland) · 16 Sep 2026

7. Gracilariopsis lemaneiformis polysaccharides extend lifespan in worms (+8.61% mean lifespan).

   “In wild-type N2 worms, GP, GP-D, and GP-H extended mean lifespan by 8.61%, 14.70%, and 21.21%, respectively”

   Model organismsin wild-type N2 wormsunfermented polysaccharide-rich fraction

   Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions · Foods (Basel, Switzerland) · 16 Sep 2026

Gracilariopsis lemaneiformis polysaccharides →

1. Perilla frutescens activate skn-1 in worms.

   Model organismsethyl acetate leaf extract

   Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway · Biogerontology · 26 Sep 2026

2. Perilla frutescens activate daf-16 in worms.

   Model organismsethyl acetate leaf extract

   Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway · Biogerontology · 26 Sep 2026

3. Perilla frutescens decrease lipid storage in worms.

   Model organismsethyl acetate leaf extract

   Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway · Biogerontology · 26 Sep 2026

4. Perilla frutescens decrease malondialdehyde in worms.

   Model organismsethyl acetate leaf extract

   Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway · Biogerontology · 26 Sep 2026

5. Perilla frutescens extend lifespan in worms.

   Model organismsethyl acetate leaf extract

   Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway · Biogerontology · 26 Sep 2026

Perilla frutescens →

1. Pimozide increases hydroxyproline in worms.

   “Transcriptomic profiling and biochemical validation reveal that pimozide markedly upregulates collagen gene expression and increases hydroxyproline content, indicating enhanced collagen synthesis.”

   Model organisms

   Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes · Antioxidants (Basel, Switzerland) · 21 Sep 2026

2. Pimozide decreases reactive oxygen species in worms.

   “pimozide-treated nematodes showed enhanced resistance to heat, ultraviolet and oxidative stress, concomitant with reduced endogenous reactive oxygen species levels.”

   Model organisms

   Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes · Antioxidants (Basel, Switzerland) · 21 Sep 2026

3. Pimozide improves locomotor function in worms.

   “pimozide improves healthspan, as evidenced by reduced age-related lipofuscin accumulation, preserved locomotor function, and decreased paralysis incidence.”

   Model organisms

   Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes · Antioxidants (Basel, Switzerland) · 21 Sep 2026

4. Pimozide decreases lipofuscin in worms.

   “pimozide improves healthspan, as evidenced by reduced age-related lipofuscin accumulation, preserved locomotor function, and decreased paralysis incidence.”

   Model organisms

   Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes · Antioxidants (Basel, Switzerland) · 21 Sep 2026

5. Pimozide extends lifespan in worms (+44.3% mean, +50.0% median, +39.8% maximum).

   “The results demonstrated that 0.1 μM pimozide significantly extends nematode lifespan, increasing mean, median, and maximum lifespans by 44.3%, 50.0%, and 39.8%, respectively.”

   Model organisms0.1 μM

   Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes · Antioxidants (Basel, Switzerland) · 21 Sep 2026

Pimozide →

1. Xiaoyao san decreases reactive oxygen species in worms.

   Model organisms

   [Xiaoyao San alleviates abnormal α‑syn aggregation and neuronal injury in a Caenorhabditis elegans model of Parkinson disease via the SKN-1 antioxidative pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026

2. Xiaoyao san decreases SNCA in worms.

   Model organisms

   [Xiaoyao San alleviates abnormal α‑syn aggregation and neuronal injury in a Caenorhabditis elegans model of Parkinson disease via the SKN-1 antioxidative pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026

3. Xiaoyao san protects against dopaminergic neuron in worms.

   Model organisms6-OHDA-induced damagedopaminergic neuron

   [Xiaoyao San alleviates abnormal α‑syn aggregation and neuronal injury in a Caenorhabditis elegans model of Parkinson disease via the SKN-1 antioxidative pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026

4. Xiaoyao san improves physical function in worms.

   Model organisms

   [Xiaoyao San alleviates abnormal α‑syn aggregation and neuronal injury in a Caenorhabditis elegans model of Parkinson disease via the SKN-1 antioxidative pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026

5. Xiaoyao san extends lifespan in worms.

   Model organismsin PD model worms

   [Xiaoyao San alleviates abnormal α‑syn aggregation and neuronal injury in a Caenorhabditis elegans model of Parkinson disease via the SKN-1 antioxidative pathway] · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 1 Sep 2026

Xiaoyao san →

1. Apigenin protects against Alzheimer's disease in worms.

   Model organismsexpressing amyloid-beta or tau

   Apigenin Improves Healthspan and Protects Against Alzheimer's Disease-Associated Proteotoxicity in C. elegans · bioRxiv · 29 Sep 2026 · Preprint

2. Apigenin decreases oxidative stress and ROS signalling in worms.

   Model organisms

   Apigenin Improves Healthspan and Protects Against Alzheimer's Disease-Associated Proteotoxicity in C. elegans · bioRxiv · 29 Sep 2026 · Preprint

3. Apigenin improves locomotor activity in worms.

   Model organismschronic exposure

   Apigenin Improves Healthspan and Protects Against Alzheimer's Disease-Associated Proteotoxicity in C. elegans · bioRxiv · 29 Sep 2026 · Preprint

4. Apigenin extends lifespan in worms.

   Model organismschronic exposure

   Apigenin Improves Healthspan and Protects Against Alzheimer's Disease-Associated Proteotoxicity in C. elegans · bioRxiv · 29 Sep 2026 · Preprint

Apigenin →

1. Peptone-free nematode growth medium improves locomotor activity in worms.

   Model organismswith PFA-killed OP50

   Peptone-free nematode growth medium improves culture stability and physiological resilience in Caenorhabditis elegans · Biogerontology · 28 Sep 2026

2. Peptone-free nematode growth medium decreases lipid storage in worms.

   Model organismswith PFA-killed OP50

   Peptone-free nematode growth medium improves culture stability and physiological resilience in Caenorhabditis elegans · Biogerontology · 28 Sep 2026

3. Peptone-free nematode growth medium decreases reactive oxygen species in worms.

   Model organismswith PFA-killed OP50

   Peptone-free nematode growth medium improves culture stability and physiological resilience in Caenorhabditis elegans · Biogerontology · 28 Sep 2026

4. Peptone-free nematode growth medium has no effect on lifespan in worms.

   Model organismswith PFA-killed OP50

   Peptone-free nematode growth medium improves culture stability and physiological resilience in Caenorhabditis elegans · Biogerontology · 28 Sep 2026

Peptone-free nematode growth medium →

1. Sonnerachromones a–g decreases reactive oxygen species in worms.

   Model organisms

   Sonnerachromones A–C from Sonneratia Apetala Delay Aging and Extend Lifespan in Caenorhabditis elegans Associated with Modulation of Telomere–Telomerase-Related Pathways · Preprints.org · 29 Sep 2026 · Preprint

2. Sonnerachromones a–g decreases lipofuscin in worms.

   Model organisms

   Sonnerachromones A–C from Sonneratia Apetala Delay Aging and Extend Lifespan in Caenorhabditis elegans Associated with Modulation of Telomere–Telomerase-Related Pathways · Preprints.org · 29 Sep 2026 · Preprint

3. Sonnerachromones a–g extends lifespan in worms.

   Review

   Sonnerachromones A–C from Sonneratia Apetala Delay Aging and Extend Lifespan in Caenorhabditis elegans Associated with Modulation of Telomere–Telomerase-Related Pathways · Preprints.org · 29 Sep 2026 · Preprint

Sonnerachromones a–g →

1. Musk ketone increases reactive oxygen species in worms.

   Model organisms0.4 to 20 mg/L24 h

   Assessing the toxicological effects of synthetic musk ketone using the Caenorhabditis elegans model · BMC pharmacology & toxicology · 9 Sep 2026

2. Musk ketone increases lipofuscin in worms.

   Model organisms0.4 to 20 mg/L24 h

   Assessing the toxicological effects of synthetic musk ketone using the Caenorhabditis elegans model · BMC pharmacology & toxicology · 9 Sep 2026

3. Musk ketone shortens lifespan in worms.

   Model organisms0.4 to 20 mg/L24 h

   Assessing the toxicological effects of synthetic musk ketone using the Caenorhabditis elegans model · BMC pharmacology & toxicology · 9 Sep 2026

Musk ketone →

1. Sonnerachromones a–c decreases telomere attrition in worms.

   Model organisms

   Sonnerachromones A–C from Sonneratia Apetala Delay Aging and Extend Lifespan in Caenorhabditis elegans Associated with Modulation of Telomere–Telomerase-Related Pathways · Preprints.org · 29 Sep 2026 · Preprint

2. Sonnerachromones a–c increases telomerase activity in worms.

   Model organisms

   Sonnerachromones A–C from Sonneratia Apetala Delay Aging and Extend Lifespan in Caenorhabditis elegans Associated with Modulation of Telomere–Telomerase-Related Pathways · Preprints.org · 29 Sep 2026 · Preprint

Sonnerachromones a–c →

1. SEX-1 knockdown impairs thermosensory function in worms.

   Model organismsloss of functionamphid neuron

   A PPAR-gamma counterpart protects worm neurons by coordinating lipids and mitochondria · bioRxiv · 29 Sep 2026 · Preprint

2. SEX-1 knockdown induces mitochondrial dysfunction in worms.

   Model organismsloss of function

   A PPAR-gamma counterpart protects worm neurons by coordinating lipids and mitochondria · bioRxiv · 29 Sep 2026 · Preprint

SEX-1 knockdown →