AgingResearch.NewsJoin free

Phenylalanine

InterventionApproved 1984

5 papers3 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

About aging: trials about aging, of every trial that tests the drug for any use.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 2 trials, none about aging, 1 with no results posted
  • Funders: Ajinomoto and 5 more
  • 1 of 1 finding with company ties
  • Humans2
  • Animals1
  • Model organisms1

Associations

3

Type 2 diabetes

upin humans1

1 study

  1. Phenylalanine raises the risk of type 2 diabetes in humans.

    “elevated plasma Phe is a significant risk factor for obesity, type 2 diabetes mellitus (T2DM) and cancer”

    Review

    Phenylalanine homeostasis in metabolic disorders: epidemiological trends, pathophysiological mechanisms, and clinical treatment

    Frontiers in endocrinology27 Mar 2026

More on Type 2 diabetes

Obesity

upin humans1

1 study

  1. Phenylalanine raises the risk of obesity in humans.

    “elevated plasma Phe is a significant risk factor for obesity, type 2 diabetes mellitus (T2DM) and cancer”

    Review

    Phenylalanine homeostasis in metabolic disorders: epidemiological trends, pathophysiological mechanisms, and clinical treatment

    Frontiers in endocrinology27 Mar 2026

More on Obesity

All-cause disability-adjusted life years

downin humans1

1 study

  1. Phenylalanine is associated with all-cause disability-adjusted life years in humans (Coeff. -38.506, p = 0.048).

    “phenylalanine (Coeff. -38.506; p = 0.048)”

    Humansmales

    Association of dietary protein and amino acid intakes with all-cause disability-adjusted life years: cross-sectional analysis of the national health and nutrition survey in Japan

    Journal of health, population, and nutrition16 Feb 2026

Trials

0 about aging, of 2

Approved

Repurposing

Trial sponsors

Funding

2 grants since 2025

American Heart AssociationUS$231kNational Institute of Diabetes and Digestive and Kidney DiseasesUS$91.5k

Latest

Nov 2025: 4Dec 2025: 0Jan 2026: 1Feb 2026: 1Mar 2026: 2Apr 2026: 2May 2026: 2Jun 2026: 3Jul 2026: 2Aug 2026: 3Sep 2026: 7Oct 2026: 027 in 12 months

Related