Proline
- 3 independent labs in 3 countries
- Funders: National Institute on Aging and others
- 1 of 6 findings with company ties
- Humans1
- Model organisms1
- Cells2
Outcomes
5Lifespan
upin R. toruloides cells1
1 study
Lifespan
upin R. toruloides cells1
Proline extends lifespan in R. toruloides cells.
“whereas proline exerts effect at 2 mM.”
Cellsunder glucose nutrimental stress2 mM
Glucosylglycerol and proline reverse the effects of glucose on Rhodosporidium toruloides lifespan
Archives of microbiology28 Mar 2024
DNA damage
downin human cells1
1 study
DNA damage
downin human cells1
Proline decreases DNA damage in human cells.
“proline treatment also mitigates several aging hallmarks, including DNA damage, senescence-associated β-galactosidase, inflammatory cytokine expressions”
Cellsin senescent cells
Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
Cell reports12 Feb 2024
Senescence-associated beta-galactosidase
downin human cells1
1 study
Senescence-associated beta-galactosidase
downin human cells1
Proline decreases senescence-associated beta-galactosidase in human cells.
“proline treatment also mitigates several aging hallmarks, including DNA damage, senescence-associated β-galactosidase, inflammatory cytokine expressions”
Cellsin senescent cells
Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
Cell reports12 Feb 2024
Mitophagy
upin human cells1
1 study
Mitophagy
upin human cells1
Proline induces mitophagy in human cells.
“Proline induces mitophagy by activating AMP-activated protein kinase α and upregulating Parkin expression”
Cellsin senescent cells
Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
Cell reports12 Feb 2024
Mitochondrial respiratory impairment
downin human cells1
1 study
Mitochondrial respiratory impairment
downin human cells1
Proline decreases mitochondrial respiratory impairment in human cells.
“senescent mesenchymal stem cells manifest severe mitochondrial respiratory impairment, which is alleviated through proline supplementation”
Cellsin senescent mesenchymal stem cells
Proline restores mitochondrial function and reverses aging hallmarks in senescent cells
Cell reports12 Feb 2024
Associations
1All-cause disability-adjusted life years
downin humans1
1 study
All-cause disability-adjusted life years
downin humans1
Proline is associated with all-cause disability-adjusted life years in humans (Coeff. -31.499, p = 0.010).
“and proline (Coeff. -31.499; p = 0.010) intakes with DALYs after adjustment”
Humansmales
Journal of health, population, and nutrition16 Feb 2026
Funding
1 grant since 2020Danmarks Frie Forskningsfond