2 papers
Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.
Genetic experiments in worms found that disrupting a muscle protein’s entry into cell nuclei preserved gene activity for the machinery of contraction during aging.Genetic experiments in worms found that disrupting a muscle protein’s entry into cell nuclei preserved gene activity for the machinery of contraction during aging.
Analysing datasets from 23 muscle donors and 30 early-progression brain donors, researchers identified matching inflammatory gene pathways across tissues.Analysing datasets from 23 muscle donors and 30 early-progression brain donors, researchers identified matching inflammatory gene pathways across tissues.
In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.
Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.Age-related gut stiffening activates smooth muscle Piezo1, triggering calcium signaling that suppresses contractile genes and slows intestinal transit.
Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.
Transcriptomic profiling of human skeletal muscle paired with cell experiments identified inflammatory macrophages and Activin A signaling as candidate regulators of…Transcriptomic profiling of human skeletal muscle paired with cell experiments identified inflammatory macrophages and Activin A signaling as candidate regulators of altered muscle stem cells.