Six-metabolite signature score
Biomarker1 paper5 findings
- Humans1
Effects
1Discrimination between metabolically healthy and unhealthy obesity
upin humans1
1 study
Discrimination between metabolically healthy and unhealthy obesity
upin humans1
Six-metabolite signature score improves discrimination between metabolically healthy and unhealthy obesity in humans (AUC 0.78 vs 0.69).
“The combined clinical-metabolomic model showed better discrimination than clinical variables alone in the test set, with AUCs of 0.78 and 0.69, respectively.”
Humansin UK Biobank adults with obesityn = 13,215
Six blood metabolites distinguish metabolic health in obesity · Frontiers in endocrinology · 11 Sep 2026
Associations
4Cardiovascular comorbidity burden
upin humans1
1 study
Cardiovascular comorbidity burden
upin humans1
Six-metabolite signature score is associated with cardiovascular comorbidity burden in humans.
“Within MHO, higher metabolomic score was associated with higher triglycerides, HbA1c, waist-to-hip ratio, lower HDL cholesterol, and greater metabolic and cardiovascular comorbidity burden.”
Humanswithin conventionally defined metabolically healthy obesity
Six blood metabolites distinguish metabolic health in obesity · Frontiers in endocrinology · 11 Sep 2026
HDL cholesterol
downin humans1
1 study
HDL cholesterol
downin humans1
Six-metabolite signature score is associated with HDL cholesterol in humans.
“Within MHO, higher metabolomic score was associated with higher triglycerides, HbA1c, waist-to-hip ratio, lower HDL cholesterol, and greater metabolic and cardiovascular comorbidity burden.”
Humanswithin conventionally defined metabolically healthy obesity
Six blood metabolites distinguish metabolic health in obesity · Frontiers in endocrinology · 11 Sep 2026
HbA1c
upin humans1
1 study
HbA1c
upin humans1
Six-metabolite signature score is associated with HbA1c in humans.
“Within MHO, higher metabolomic score was associated with higher triglycerides, HbA1c, waist-to-hip ratio, lower HDL cholesterol, and greater metabolic and cardiovascular comorbidity burden.”
Humanswithin conventionally defined metabolically healthy obesity
Six blood metabolites distinguish metabolic health in obesity · Frontiers in endocrinology · 11 Sep 2026
Triglyceride
upin humans1
1 study
Triglyceride
upin humans1
Six-metabolite signature score is associated with triglyceride in humans.
“Within MHO, higher metabolomic score was associated with higher triglycerides, HbA1c, waist-to-hip ratio, lower HDL cholesterol, and greater metabolic and cardiovascular comorbidity burden.”
Humanswithin conventionally defined metabolically healthy obesity
Six blood metabolites distinguish metabolic health in obesity · Frontiers in endocrinology · 11 Sep 2026
Latest
1Six blood metabolites distinguish metabolic health in obesity
A combined clinical-metabolomic model discriminated healthy from unhealthy obesity with an AUC of 0.78, compared with 0.69 for clinical variables…A combined clinical-metabolomic model discriminated healthy from unhealthy obesity with an AUC of 0.78, compared with 0.69 for clinical variables alone.