1 paper
Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.
In a mouse heart attack experiment, particles released by aged stem cells engineered to produce more apelin, a signalling protein, improved heart function.In a mouse heart attack experiment, particles released by aged stem cells engineered to produce more apelin, a signalling protein, improved heart function.
Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.Blocking the prostaglandin E2 pathway or targeting cellular senescence reduces uterine scarring and improves tissue repair in mouse models of cesarean defects.
The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.The itaconate derivative reduces fibrosis and lipid buildup while curbing oxidative stress through AMPK signaling pathways.
The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease.The immunosuppressant suppresses epithelial-mesenchymal transition and promotes p53 degradation via the SFN-MDM2 pathway to curb fibrotic lung disease.
Supplementing aged mice with heat-killed Neisseria flavescens restored their serum metabolome, liver transcriptome and gut microbiome toward younger states.Supplementing aged mice with heat-killed Neisseria flavescens restored their serum metabolome, liver transcriptome and gut microbiome toward younger states.