Frailty
Biomarker5 papers4 findings
- Humans5
Effects
1Reoperation
no changein humans1
1 study
Reoperation
no changein humans1
Frailty has no effect on reoperation in humans.
Humansafter ORIF
Frailty predicts mortality after tibial plateau fracture surgery · The journal of knee surgery · 29 Sep 2026
Associations
3Survival
downin humans1
1 study
Survival
downin humans1
Frailty is associated with survival in humans.
Humansundergoing radical cystectomy for bladder cancer
Frailty and dementia worsen care after cystectomy in older adults · Journal of geriatric oncology · 1 Oct 2026
Skilled nursing facility admission
upin humans1
1 study
Skilled nursing facility admission
upin humans1
Frailty is associated with skilled nursing facility admission in humans.
Humansundergoing radical cystectomy for bladder cancer
Frailty and dementia worsen care after cystectomy in older adults · Journal of geriatric oncology · 1 Oct 2026
Mortality
upin humans1
1 study
Mortality
upin humans1
Frailty predicts mortality in humans (aOR 8.4, 95% CI: 1.7-61.2).
Humansadjusted for age, fracture complexity, and reduction
Frailty predicts mortality after tibial plateau fracture surgery · The journal of knee surgery · 29 Sep 2026
Latest
110Combined frailty and metabolic index tracks multimorbidity risk
Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic…Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic multimorbidity.
Early cognitive frailty is reversible in rural older adults
In older adults with reversible cognitive frailty, recovery intensity to cognitive impairment alone was 0.429 versus 0.224 for deterioration to…In older adults with reversible cognitive frailty, recovery intensity to cognitive impairment alone was 0.429 versus 0.224 for deterioration to potentially reversible cognitive frailty.
Metabolic signature links frailty to coronary artery disease
A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year…A 36-metabolite signature mediated an estimated 18.5% of the association between frailty and incident coronary artery disease over a median 14.8-year follow-up.
Electronic frailty index predicts CAR-T outcomes in older adults
Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.Very frail older patients had worse overall survival (HR=1.64) and event-free survival (HR=2.02) after CAR-T therapy than robust or prefrail peers.
Impact of frailty on outcomes in older patients after curative gastrectomy for cancer: a matched-pair analysis
Persistent depression speeds frailty accumulation in older adults
Across 57,894 older adults, a persistent high depression burden predicted faster frailty accumulation at 1.42 × 10⁻³/year and elevated odds of…Across 57,894 older adults, a persistent high depression burden predicted faster frailty accumulation at 1.42 × 10⁻³/year and elevated odds of incident frailty.
Age and frailty interaction models predict hip fracture mortality
Across 115,643 patients, predicted 30-day mortality ranged from 0.48% to 32.06% depending on age, frailty, and surgical fixation type.Across 115,643 patients, predicted 30-day mortality ranged from 0.48% to 32.06% depending on age, frailty, and surgical fixation type.
Midlife mental health problems linked to frailty decades later
In a 35-year study of 27,958 adults, baseline mental health issues at ages 35–49 were linked to 0.52 higher Fried frailty scores after age 70.In a 35-year study of 27,958 adults, baseline mental health issues at ages 35–49 were linked to 0.52 higher Fried frailty scores after age 70.