Contractility

Papers on contractility

1,167 papers54 new in 30 days

Monday, October 26

Sunday, October 25

Saturday, October 24

Tuesday, October 20

Monday, October 19

Sunday, October 18

Saturday, October 17

Scientific Reports

Muscle function improved after training in older adults

In a before-and-after study, 37 older adults trained twice weekly for 12 weeks, with gains in physical performance and force from individual muscle fibers.In a before-and-after study, 37 older adults trained twice weekly for 12 weeks, with gains in physical performance and force from individual muscle fibers.

Figure from Scientific Reports
Single-arm trial · 37 peopleMuscle

Friday, October 16

Thursday, October 15

Wednesday, October 14

Tuesday, October 13

bioRxiv

A protein supports force in stretched animal muscle fibers

Experiments in animal muscle fibers found that reducing the protein plakoglobin impaired the extra activation of force-producing structures as their contractile units…Experiments in animal muscle fibers found that reducing the protein plakoglobin impaired the extra activation of force-producing structures as their contractile units lengthened.

Muscle atrophy is associated with reduced plakoglobin membrane localization.
Preprint: experiments in animalsMuscle

Sunday, October 11

Thursday, October 8

bioRxiv

Disrupting protein entry delays signs of muscle aging in worms

Genetic experiments in worms found that disrupting a muscle protein’s entry into cell nuclei preserved gene activity for the machinery of contraction during aging.Genetic experiments in worms found that disrupting a muscle protein’s entry into cell nuclei preserved gene activity for the machinery of contraction during aging.

Identification of UNC-27 as a regulator of sarcomeric gene expression during adulthood.
Preprint: experiments in wormsMuscle
GeroScience

Resolvin E1 aids muscle repair after injury in aged mice

In aged mice, treatment after injury cleared inflammatory cells faster, expanded muscle-forming cells, and trended toward improved muscle contraction.In aged mice, treatment after injury cleared inflammatory cells faster, expanded muscle-forming cells, and trended toward improved muscle contraction.

Figure from GeroScience
Experiments in miceMuscle

Wednesday, October 7

Aging Cell

Exercise or drugs improved heart function in aging mice

A nine-month randomized experiment in 12-month-old mice compared exercise (11 mice), two drugs (15), both (16) and natural aging (12); the interventions improved heart…A nine-month randomized experiment in 12-month-old mice compared exercise (11 mice), two drugs (15), both (16) and natural aging (12); the interventions improved heart performance.

Mice given aerobic exercise, senolytics, or both combined for 9‐months display superior myocardial function to naturally aged mice.
Experiments in miceAerobic exercise
Nature Communications

Probiotic shortened gut transit time in older adults

A randomized, double-blind trial also found changes in gut bacteria, including suppression of bacteria that produce an enzyme involved in processing bile acids.A randomized, double-blind trial also found changes in gut bacteria, including suppression of bacteria that produce an enzyme involved in processing bile acids.

Figure from Nature Communications
Randomized trial in peopleGut and microbiome
Research Square

DNA damage differed by sex in mice with impaired DNA repair

Experiments in mice with impaired DNA repair identified a female-specific metabolic pathway; a dietary supplement restored muscle force and metabolic profiles in females.Experiments in mice with impaired DNA repair identified a female-specific metabolic pathway; a dietary supplement restored muscle force and metabolic profiles in females.

Type II fiber-specific ERCC1 deletion leads to sex-specific accumulation of DNA damage.
Preprint: experiments in miceDNA repair

Tuesday, October 6

Physiological Reports

Microbial compounds limited muscle loss in aged mice

In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilized.In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilized.

PAS attenuates disuse‐induced loss of muscle size in aged mice.
Experiments in miceMuscle

Sunday, October 4

Saturday, October 3

Friday, October 2