Contractility

Papers on contractility

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ESC Congress 2026 Abstract

Exercise reduces blood vessel stiffening in hypertensive mice

In an experiment in male mice with induced high blood pressure, treadmill exercise restored a vessel protein and lessened structural changes in vessel walls.In an experiment in male mice with induced high blood pressure, treadmill exercise restored a vessel protein and lessened structural changes in vessel walls.

Artery cross-sections show an open vessel beside a mouse on a treadmill and a narrowed, thick-walled gray vessel beside a resting mouse, with cells around them.
Mouse studyAerobic exercise
ESC Congress 2026 Abstract

A chemical signal lowers energy output in blood vessel muscle cells

In experiments with blood vessel muscle cells, the signal also promoted an inflammatory state and impaired mitochondria, the cells’ energy-producing structures.In experiments with blood vessel muscle cells, the signal also promoted an inflammatory state and impaired mitochondria, the cells’ energy-producing structures.

Blood vessel muscle cells contain intact folded mitochondria beside gray cells with fragmented mitochondria and dark clusters, with a mouse above.
Animal cell studyMechanisms
ESC Congress 2026 Abstract

Klotho preserves contraction timing in human heart slices

Failing heart slices from eight patients preserved contraction timing and improved calcium handling when treated with soluble Klotho for two weeks.Failing heart slices from eight patients preserved contraction timing and improved calcium handling when treated with soluble Klotho for two weeks.

Heart muscle slices show orderly dark blue-green fibers beside irregular gray fibers, with a protein, a pig, and compact and enlarged heart sections.
Human cell studyInterventions
ESC Congress 2026 Abstract

Mice lacking a protein fragment develop weaker hearts with age

Mouse experiments found the fragment in heart muscle cells’ DNA-containing centers, near genes involved in heart structure and stress responses.Mouse experiments found the fragment in heart muscle cells’ DNA-containing centers, near genes involved in heart structure and stress responses.

Mouse heart sections beside small mice show a contracted chamber with dark fragments in cell nuclei and a wider chamber with those fragments absent.
Mouse studyMechanisms