KISSPEPTIN-10

1. KISSPEPTIN-10 increases mineral nodule deposition in mouse cells.

   “In cell culture, all concentrations of Kp10 increased the deposition of OBL mineral nodules but did not affect OCL differentiation.”

   Cells10-8, 10-7, or 10-6 M

   SAT-807 Kisspeptin Prevents Bone Loss Caused by the Lack of Estrogen in Ovariectomized Rodents

   ENDO 2025 abstract·22 Oct 2025

1. KISSPEPTIN-10 decreases inflammation in mice.

   “Kp10 also prevented the increases in Tnf-α and Il-6 and the decrease in Alp expression in the femur of OVX mice.”

   Animalsovariectomized micefemur30 daysfemales

   SAT-807 Kisspeptin Prevents Bone Loss Caused by the Lack of Estrogen in Ovariectomized Rodents

   ENDO 2025 abstract·22 Oct 2025

More on Inflammation

1. KISSPEPTIN-10 decreases RANKL/OPG ratio in mice.

   “In OVX mice, 1 nmol Kp10 prevented the rise in plasma RANKL/OPG ratio and the reduction in BV, BV/TV, Tb.N, and Tb.Th.”

   Animalsovariectomized miceplasma1 nmol/day30 daysfemales

   SAT-807 Kisspeptin Prevents Bone Loss Caused by the Lack of Estrogen in Ovariectomized Rodents

   ENDO 2025 abstract·22 Oct 2025

More on RANKL/OPG ratio

1. KISSPEPTIN-10 increases bone volume ratio in rats.

   “Kp10 treatment starting 1 day after ovariectomy was as effective as E2 in preventing the reductions in BV, BV/TV, and Tb.N and the increase in Tb.Sp”

   Animalsovariectomy prevention protocolfemur1 nmol/day30 daysfemales

   SAT-807 Kisspeptin Prevents Bone Loss Caused by the Lack of Estrogen in Ovariectomized Rodents

   ENDO 2025 abstract·22 Oct 2025

More on Bone volume ratio