CDKN2A
GeneHomo sapiens7 papersHGNC 1787NCBI Gene 1029Taxon 9606
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10Pathogenic modulators of cellular senescence
DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
medRxiv · Simpson DJ et al.
Heart Failure: Lipid Metabolism Disorders Driving Cellular Senescence Through a Vicious Cycle, and Possible Intervention Strategies
Extracellular vesicles carrying two microRNAs reduce vascular aging markers in progeria cells
Vesicles from melatonin-treated stem cells targeted SRSF1 and SP1 to lower progerin and cellular prion protein in cell models.
Pharmacological research · Joo EY et al.
Stress-Induced Senescence of Human Umbilical Cord Mesenchymal Stromal Cells Caused by Mitomycin C
Aqueous Extract of Buddleja globosa Modulates Oxidative Stress-Induced Senescence-Associated Responses in THP-1-Derived Macrophages
Loss of adenosine deaminase impairs DNA repair and triggers astrocyte senescence in ALS
Disrupted purine metabolism downstream of TDP43 dysfunction correlates with disease progression and drives cellular senescence in sporadic amyotrophic lateral sclerosis.
International journal of molecular sciences · Hall B et al.
CD47 blockade reduces doxorubicin-induced cardiac aging in male mice
Inhibiting CD47 lessens heart dysfunction and blunts cellular senescence caused by the chemotherapy drug doxorubicin.
Physiological reports · Yan A et al.