Review
Neuroinflammation and metabolic reprogramming in Parkinson's disease
Abstract · CC BY
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the pathological accumulation of Lewy bodies composed predominantly of aggregated α-synuclein (αSyn).
- Chronic inflammation
- Deregulated nutrient-sensing
- Loss of proteostasis
- Mitochondrial dysfunction
- AMPK signalling
- Hypoxia and HIF signalling
- Lipid and ceramide metabolism
- NF-κB signalling
- NLRP3 inflammasome
- Oxidative stress and ROS signalling
- mTOR signalling
- Parkinson's disease
The paper
Neuroinflammation and metabolic reprogramming in Parkinson's disease
Fu Y, Yu J, Xu L et al.
Frontiers in Immunology · 11 Sep 2026