Causal inference
Method17 papers
- Humans15
- In silico2
Latest
17Causal discovery platform maps vascular metabolic pathways
In data from 720,000 people, the self-evolving system evaluated 2,031 causal questions and identified blood pressure as a convergence node for…In data from 720,000 people, the self-evolving system evaluated 2,031 causal questions and identified blood pressure as a convergence node for vascular outcomes.
Covariate Selection in Physical Activity Epidemiology: Too Little, Too Much, or Just Right?
Sex hormone-binding globulin raises lumbar fracture risk
Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone…Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone density.
Diverse diet protects kidneys while carb restriction raises risk
Genetically predicted unrestricted eating reduced renal failure risk (odds ratio 0.1269), while avoiding sugar and wheat increased susceptibility.Genetically predicted unrestricted eating reduced renal failure risk (odds ratio 0.1269), while avoiding sugar and wheat increased susceptibility.
Early ablation is linked to lower cardiovascular risk after stroke
At 36 months, early ablation was linked to 1.54 more event-free months and an 11.17% absolute risk reduction in major adverse cardiovascular events…At 36 months, early ablation was linked to 1.54 more event-free months and an 11.17% absolute risk reduction in major adverse cardiovascular events versus medical therapy.
Statins cut Alzheimer's risk but raise other dementia risks
A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in…A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in Alzheimer's disease.
Genetically predicted TNF-beta protects against sarcopenia traits in humans
A Mendelian randomization analysis of 91 circulating inflammatory markers identified tumor necrosis factor-beta as causally linked to better muscle…A Mendelian randomization analysis of 91 circulating inflammatory markers identified tumor necrosis factor-beta as causally linked to better muscle mass, grip strength, and walking pace.
Plasma asparagine links to lower cardioembolic stroke risk
In Mendelian randomization, plasma free asparagine showed an odds ratio of 0.852 for cardioembolic stroke, whereas the glutamine-to-asparagine ratio…In Mendelian randomization, plasma free asparagine showed an odds ratio of 0.852 for cardioembolic stroke, whereas the glutamine-to-asparagine ratio yielded an odds ratio of 1.148.