Foundation models
Method9 papers
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Latest
8RaiLED-AD: Rationale-Guided Knowledge Transfer for Alzheimer's Disease Prediction from Electronic Health Records
Speech model flags cognitive decline and generates explanations
Tested across six dataset and task conditions, the bilingual framework outperformed three baselines while directly generating natural-language…Tested across six dataset and task conditions, the bilingual framework outperformed three baselines while directly generating natural-language explanations for clinicians.
Causal discovery platform maps vascular metabolic pathways
In data from 720,000 people, the self-evolving system evaluated 2,031 causal questions and identified blood pressure as a convergence node for…In data from 720,000 people, the self-evolving system evaluated 2,031 causal questions and identified blood pressure as a convergence node for vascular outcomes.
Facial foundation model estimates clinical biomarkers
Pretrained on 10 million images, the model assessed 62 biomarkers across eight physiological systems, reaching a median Pearson's r of 0.172 across…Pretrained on 10 million images, the model assessed 62 biomarkers across eight physiological systems, reaching a median Pearson's r of 0.172 across four cohorts.
Language model multimorbidity score predicts mortality in adults
Across eight external cohorts, the score yielded C-indices of 0.67 to 0.86, outperforming recalibrated conventional comorbidity indices by absolute…Across eight external cohorts, the score yielded C-indices of 0.67 to 0.86, outperforming recalibrated conventional comorbidity indices by absolute gains of 0.12 to 0.21.
Simple anatomical features match complex AI models on brain MRIs
Across about 80,000 human participants, simple anatomical measurements performed as well as complex AI models while improved pretraining boosted…Across about 80,000 human participants, simple anatomical measurements performed as well as complex AI models while improved pretraining boosted biological age estimation.
Distilled language models improve multimorbidity scoring
Compact models trained on synthetic UK Biobank cohorts predicted patient survival with concordance indices reaching 0.91 without exposing real…Compact models trained on synthetic UK Biobank cohorts predicted patient survival with concordance indices reaching 0.91 without exposing real clinical data.
Single-cell foundation models show task-dependent utility for aging biology research
A benchmark across 2.5 million single-cell transcriptomes reveals strengths in detecting rare cell states and gene networks, though simple gene sets…A benchmark across 2.5 million single-cell transcriptomes reveals strengths in detecting rare cell states and gene networks, though simple gene sets predicted age better.
Retinal imaging model predicts age and reveals sex differences in human aging
The retinal age gap correlates with mortality, disease risks, and sex-specific genetic pathways in more than 71,000 UK Biobank participants.The retinal age gap correlates with mortality, disease risks, and sex-specific genetic pathways in more than 71,000 UK Biobank participants.