Oleic acid

  • 2 independent labs in 1 country
  • Humans1
  • Animals3

Outcomes

2

Reactive microglia

downin humans1

1 study
  1. Oleic acid decreases reactive microglia in humans (β=‐0.18, SE=0.08, p = 0.03).

    “oleic acid (mono‐unsaturated fatty acid) was negatively associated with activated hippocampal microglia (Q5 vs. Q1: β=‐0.18, SE=0.08, p = 0.03)”

    Humanscontrolled for age at death, sex, education; Q5 vs. Q1hippocampus7.2±4.4 yearsn = 237

    The MIND diet association with lower microglial inflammation in the hippocampus: A Community‐Based Neuropathologic Study

    AAIC 2025 abstract23 Dec 2025

More on Reactive microglia

Periodontal bone destruction

downin mice1

1 study
  1. Oleic acid protects against periodontal bone destruction in mice.

    “whereas an OA-enriched diet (ED) has a protective effect.”

    Animalsin response to P. gingivalis infection

    Fighting Age-Associated Bone Loss in Periodontitis with Dietary Interventions

    Journal of dental research18 Oct 2025

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