Oleic acid
- 2 independent labs in 1 country
- Humans1
- Animals3
Outcomes
2Reactive microglia
downin humans1
1 study
Reactive microglia
downin humans1
Oleic acid decreases reactive microglia in humans (β=‐0.18, SE=0.08, p = 0.03).
“oleic acid (mono‐unsaturated fatty acid) was negatively associated with activated hippocampal microglia (Q5 vs. Q1: β=‐0.18, SE=0.08, p = 0.03)”
Humanscontrolled for age at death, sex, education; Q5 vs. Q1hippocampus7.2±4.4 yearsn = 237
AAIC 2025 abstract23 Dec 2025
Periodontal bone destruction
downin mice1
1 study
Periodontal bone destruction
downin mice1
Oleic acid protects against periodontal bone destruction in mice.
“whereas an OA-enriched diet (ED) has a protective effect.”
Animalsin response to P. gingivalis infection
Fighting Age-Associated Bone Loss in Periodontitis with Dietary Interventions
Journal of dental research18 Oct 2025
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