Reactive microglia

1. Oleic acid decreases reactive microglia in humans (β=‐0.18, SE=0.08, p = 0.03).

   “oleic acid (mono‐unsaturated fatty acid) was negatively associated with activated hippocampal microglia (Q5 vs. Q1: β=‐0.18, SE=0.08, p = 0.03)”

   Humanscontrolled for age at death, sex, education; Q5 vs. Q1hippocampus7.2±4.4 yearsn = 237

   The MIND diet association with lower microglial inflammation in the hippocampus: A Community‐Based Neuropathologic Study

   AAIC 2025 abstract·23 Dec 2025

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1. Mind diet decreases reactive microglia in humans (β=‐0.035, SE=0.02, p = 0.045).

   “Higher MIND diet scores during the follow‐up were associated with fewer reactive microglia (i.e., less neuroinflammation) in the hippocampus”

   Humanscontrolled for age at death, sex, education, calories, and AD pathologyhippocampus7.2±4.4 yearsn = 237

   The MIND diet association with lower microglial inflammation in the hippocampus: A Community‐Based Neuropathologic Study

   AAIC 2025 abstract·23 Dec 2025

More on Mind diet