Polygenic Risk Scores for modifiable risk factors show sex‐specific associations in Alzheimer’s Disease

Abstract

Background: Alzheimer’s disease (AD) is a major public health crisis, with two‐thirds of diagnoses occurring in women. The 2024 Lancet Commission of dementia prevention attributed 45% of AD cases to modifiable risk factors such as physical activity, cholesterol levels, and education; which also have sex specific prevalences.