Reproductive aging
Disease1 paper1 finding
Interventions
1Phytochemicals
downin reviews1
1 study
Phytochemicals
downin reviews1
Phytochemicals protect against reproductive aging.
Reviewreproductive aging
Mitochondrial-Targeted Phytochemicals in Reproductive Aging: Mechanisms and Translational Potential · Reproductive medicine and biology · 1 Jan 2026
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21Cardiovascular health and depression among postpartum women in the United States
Elamipretide improves oocyte quality and restores fertility in aged mice
The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.The peptide also boosted maturation and fertilization in aged human oocytes by activating the vitamin B6 and VEGF pathway.
Tamoxifen causes temporary ovarian disruption without altering long-term mouse aging trajectories
A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.A new preprint shows tamoxifen-inducible mouse models remain valid for ovarian aging research despite transient disruptions to estrous cycling.
Ovarian stiffness and fibrosis mark reproductive aging in women
Shear wave elastography and transcriptomic profiling show that ovarian fibrosis correlates with reduced oocyte yield and follicular efficiency.Shear wave elastography and transcriptomic profiling show that ovarian fibrosis correlates with reduced oocyte yield and follicular efficiency.
Ovarian stiffness increases with age and tracks with declining egg yield
Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.Researchers combined imaging, matrix profiling, and single-cell sequencing to show how ovarian fibrosis develops in women over time.
Inhibiting CHK2 improves oocyte quality and reduces ovarian inflammation in aged mice
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte…A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
Declining ribosome function drives reproductive aging in fruit fly and mouse oocytes
A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.A genetic screen and functional assays show that falling translational capacity causes meiotic and developmental defects during oocyte aging.
Childhood ADHD brain patterns link to markers of late-life aging
In two human cohorts, Alzheimer's genetic risk predicted childhood ADHD, while an ADHD-related brain profile correlated with reproductive aging…In two human cohorts, Alzheimer's genetic risk predicted childhood ADHD, while an ADHD-related brain profile correlated with reproductive aging markers and poorer late-life cognition.