Mitochondrial DNA damage
Biomarker1 paper1 finding
- Cells1
Interventions
1Tardbp G376D mutation
upin human cells1
1 study
Tardbp G376D mutation
upin human cells1
Tardbp G376D mutation increases mitochondrial DNA damage in human cells.
“This was accompanied by pronounced disruption of mitochondrial cristae architecture and accumulation of mitochondrial DNA damage, indicating compromised mitochondrial genome integrity.”
Cellsdermal fibroblast
Mitochondrial Quality Control Impairment Is a Hallmark of TDP-43G376D ALS Patient-Derived Fibroblasts · Antioxidants (Basel, Switzerland) · 22 Aug 2026