6 papers1 finding
Autophagy
downin mice1
Autophagy protects against myopathy in mice.
“Using a muscle-specific CMA-deficient mouse model, we show that CMA loss leads to progressive myopathy”
Animalsmuscle-specific CMA deficiencyskeletal muscle
Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy
Nature metabolism3 Dec 2025
1 trialPhase 445 people
University of Oslo School of Pharmacy
1 trialPhase 4
1 trialPhase 17 people
National Institute of Neurological Disorders and StrokeUS$5.4mNational Institute on AgingUS$148.7k
National Institute of Neurological Disorders and StrokeUniversity of MinnesotaUS$1m2023–2028
Resistance exercise to mitigate glucocorticoid myopathy during Alzheimer’s
National Institute on AgingFlorida State UniversityUS$74.3k2023–2026
National Institute of Neurological Disorders and StrokeUniversity of MinnesotaUS$4.4m2023–2026
Experiments with lab-grown liver and muscle cells linked statin exposure to lower levels of insulin-like growth factor-1, a growth signal.Experiments with lab-grown liver and muscle cells linked statin exposure to lower levels of insulin-like growth factor-1, a growth signal.
Deleting cardiolipin synthase in young mice induced age-like fiber shifts, while restoring its expression reversed atrophy and rescued premature mortality.Deleting cardiolipin synthase in young mice induced age-like fiber shifts, while restoring its expression reversed atrophy and rescued premature mortality.