Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.
Experiments in aged mice with or without AMPKα2, against untreated aged miceInterventions
Limit: Group sizes were unreported, leaving the precision of heart-function improvements unclear
Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.Mice with one working copy of the protein’s gene had enlarged, scarred hearts and poorer pumping, resembling changes in aged mice.
An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.