Transcriptional age

2 papers2 findings

Humans1
Animals1

Interventions

1

Induced mononuclear phagocytes

downin mice1

1 study

Induced mononuclear phagocytes decrease transcriptional age in mice.
“iMPs decrease the transcriptional age of several hippocampal cell types.”
Animalshippocampal cell types
Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease
Advanced science (Weinheim, Baden-Wurttemberg, Germany)24 Aug 2025

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Upstream

1

Bipolar disorder

no changein humans1

1 study

Bipolar disorder has no effect on transcriptional age in humans.
“but not on transcriptional age”
Humansversus controlsblood
Genome-wide methylation biomarkers and biological aging in patients with bipolar disorder characterized for lithium response
European psychiatry : the journal of the Association of European Psychiatrists1 Oct 2025

More on Bipolar disorder

Latest

9 in 12 months

bioRxiv24 Sep

Age-Related Remodeling of Cross-Tissue Transcriptional Coordination in the Human Motor System

Preprint: computational studyMechanisms

Experimental Eye Research19 Sep

A new omics view of retinal aging: Cell-type vulnerability, spatial niches, and disease susceptibility

ReviewEye

Cureus24 Aug

Nicotinamide Mononucleotide (NMN) Prevents Age-Associated Transcriptional Drift in a Tissue-Dependent Manner: Mechanistic Leads From Ras-Related Protein Rab-11A-Mediated Trafficking and Carnitine Palmitoyltransferase 2-Linked Fatty Acid Oxidation

Computational studyNicotinamide mononucleotide

Nature20 Aug

Human brain organoids record the passage of time over multiple years

Experiments in human cellsMechanisms

bioRxiv13 Feb

A stem cell aging clock links biological age deviation to clinical outcome in acute myeloid leukemia

Preprint: cohort study of 84 peopleAcute myeloid leukemia

bioRxiv5 Feb

Overmaturation as a major trajectory of naïve CD4 T cell aging

Preprint: cross-sectional study in peopleBlood and immune system

GSA 2025 Abstract3 Jan

Universal Single-Cell Transcriptomic Aging Clock powered by LLMs reveals targets to slow cellular aging

Computational studyBiomarkers

Aging Cell24 Nov

Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain

Experiments in monkeysDietary restriction

Preprints.org24 Nov

Negative Correlation Between Chronological Age and NDRG1 Expression in Mesenchymal Stromal Cells (MSCs): A Candidate Biomarker for Transcriptional Aging

Preprint: computational studyBiomarkers

European Psychiatry1 Oct

Genome-wide methylation biomarkers and biological aging in patients with bipolar disorder characterized for lithium response

Case-control study in peopleBipolar disorder