Pace of Aging
Biomarker3 papers9 findings
- Humans3
Interventions
1Social isolation
no changein humans1Low certainty
1 study
Social isolation
no changein humans1Low certainty
Social isolation has no effect on Pace of Aging in humans.
“We found that baseline loneliness, but not social isolation, predicted faster PoA”
Humansbaseline social isolation predicting follow-up PoAn = 5,659
Social Isolation, Loneliness, and Pace of Aging Among Older Adults in the English Longitudinal Study of Ageing · GSA 2025 abstract · 31 Dec 2025
Effects
1Healthspan
downin humans1
1 study
Healthspan
downin humans1
Pace of Aging decreases healthspan in humans.
“This imbalance led to an extended duration of life spent in poor health. The HLE–LE gap was consistently wider among those aging faster across all outcomes.”
Humans
Healthspan-Lifespan Trade-off Under Accelerated Biological Aging: Evidence From The Health And Retirement Study · GSA 2025 abstract · 31 Dec 2025
Associations
6Loneliness
upin humans1Low certainty
1 study
Loneliness
upin humans1Low certainty
Pace of Aging predicts loneliness in humans (β = 0.12).
“In turn, faster PoA prospectively predicted higher levels of both loneliness (β = 0.12) and social isolation (β = 0.11) at follow-up”
Humansindependent of baseline levelsn = 5,659
Social Isolation, Loneliness, and Pace of Aging Among Older Adults in the English Longitudinal Study of Ageing · GSA 2025 abstract · 31 Dec 2025
Loneliness predicts Pace of Aging in humans (β = 0.03).
“We found that baseline loneliness, but not social isolation, predicted faster PoA (β = 0.03)”
Humansbaseline loneliness predicting follow-up PoAn = 5,659
Social Isolation, Loneliness, and Pace of Aging Among Older Adults in the English Longitudinal Study of Ageing · GSA 2025 abstract · 31 Dec 2025
Social isolation
upin humans1Low certainty
1 study
Social isolation
upin humans1Low certainty
Pace of Aging predicts social isolation in humans (β = 0.11).
“In turn, faster PoA prospectively predicted higher levels of both loneliness (β = 0.12) and social isolation (β = 0.11) at follow-up”
Humansindependent of baseline levelsn = 5,659
Social Isolation, Loneliness, and Pace of Aging Among Older Adults in the English Longitudinal Study of Ageing · GSA 2025 abstract · 31 Dec 2025
Functional decline
upin humans1
1 study
Functional decline
upin humans1
Pace of Aging raises the risk of functional decline in humans.
“individuals with faster pace of aging had increased risk of transitioning from healthy to unhealthy states”
Humans
Healthspan-Lifespan Trade-off Under Accelerated Biological Aging: Evidence From The Health And Retirement Study · GSA 2025 abstract · 31 Dec 2025
Disability
upin humans1
1 study
Disability
upin humans1
Pace of Aging predicts disability in humans.
“participants with faster Pace of Aging were at increased risk of cognitive impairment, incident chronic disease, disability, and death over follow-up compared to those with slower Pace of Aging”
Humansindependent of agen = 13,379
QUANTIFYING PACE OF AGING AMONG OLDER ADULTS: AN ANALYSIS WITH HEALTH AND RETIREMENT STUDY · GSA 2024 abstract · 31 Dec 2024
Cognitive impairment
upin humans1
1 study
Cognitive impairment
upin humans1
Pace of Aging predicts cognitive impairment in humans.
“participants with faster Pace of Aging were at increased risk of cognitive impairment, incident chronic disease, disability, and death over follow-up compared to those with slower Pace of Aging”
Humansindependent of agen = 13,379
QUANTIFYING PACE OF AGING AMONG OLDER ADULTS: AN ANALYSIS WITH HEALTH AND RETIREMENT STUDY · GSA 2024 abstract · 31 Dec 2024
Mortality
upin humans1HR 1.94
1 study
Mortality
upin humans1HR 1.94
Pace of Aging predicts mortality in humans (HR=1.94 95%CI[1.82-2.08]).
“participants with faster Pace of Aging were at increased risk of cognitive impairment, incident chronic disease, disability, and death over follow-up compared to those with slower Pace of Aging (e.g. mortality HR=1.94 95%CI[1.82-2.08])”
Humansindependent of agen = 13,379
QUANTIFYING PACE OF AGING AMONG OLDER ADULTS: AN ANALYSIS WITH HEALTH AND RETIREMENT STUDY · GSA 2024 abstract · 31 Dec 2024
Latest
24Hormone therapy linked to lower breast cancer mortality
Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death…Compared with never-users, hormone therapy ever-users had adjusted hazard ratios, which compare event rates over time, of 0.72 for breast cancer death and 1.17 for diagnosis.
Early-life mitochondrial DNA mutations drive age-related pathology in mice
Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.Manipulating mitochondrial fusion can alter tissue-specific selection against deleterious variants that arise early in development.
Diet benefits for epigenetic aging may reflect familial factors
In Danish twins, adherence linked cross-sectionally to slower DunedinPACE, but within-pair and longitudinal analyses attenuated the associations over…In Danish twins, adherence linked cross-sectionally to slower DunedinPACE, but within-pair and longitudinal analyses attenuated the associations over 12 years.