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Induced mononuclear phagocytes

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

5

Cognitive function

upin mice1

1 study

  1. Induced mononuclear phagocytes improve cognitive function in mice.

    “Finally, iMPs improve cognition in both young and aging 5×FAD mice”

    Animals5×FAD mice

    Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)24 Aug 2025

Serum amyloid

downin mice1

1 study

  1. Induced mononuclear phagocytes decrease serum amyloid in mice.

    “Plasma proteomic analyses reveal that iMPs can also reverse age-associated increases in serum amyloid levels.”

    Animalsage-associated increasesplasma

    Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)24 Aug 2025

More on Serum amyloid

Transcriptional age

downin mice1

1 study

  1. Induced mononuclear phagocytes decrease transcriptional age in mice.

    “iMPs decrease the transcriptional age of several hippocampal cell types.”

    Animalshippocampal cell types

    Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)24 Aug 2025

More on Transcriptional age

Inflammation

downin mice1

1 study

  1. Induced mononuclear phagocytes decrease inflammation in mice.

    “In aging mice, intravenous delivery of induced mononuclear phagocytes (iMPs) improves performance in hippocampus-dependent cognitive tasks, increases neural health, and reduces neuroinflammation.”

    Animals

    Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)24 Aug 2025

More on Inflammation

Hippocampus-dependent cognitive performance

upin mice1

1 study

  1. Induced mononuclear phagocytes improve hippocampus-dependent cognitive performance in mice.

    “In aging mice, intravenous delivery of induced mononuclear phagocytes (iMPs) improves performance in hippocampus-dependent cognitive tasks”

    Animalshippocampus

    Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)24 Aug 2025

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