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Nature

Human brain organoids record the passage of time over multiple years

By Irene Faravelli, Noelia Antón-Bolaños, Anqi Wei, Show 20 more authorsPaola Arlotta
Fig. 1. Cortical organoids undergo progressive maturation during long-term culture.
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Fig. 1. Cortical organoids undergo progressive maturation during long-term culture.Cortical organoids undergo progressive maturation during long-term culture.Faravelli et al.
Experiments in human cellsMechanisms

5 years, declared ties to: Foresite Labs, Avatar Bio, Celsius Therapeutics and 10 more

Paper

The paper

Irene Faravelli, Noelia Antón-Bolaños, Anqi Wei, Show 20 more authorsPaola Arlotta

Broad Institute

Nature, 19 Aug 2026

doi.org/10.1038/s41586-026-10877-xPubMed 42618795

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