An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.
Genetic association study of participants in human artery disease genetic studiesMechanisms
Limit: The genetic signals concern a modelled ASCVD common factor rather than directly measured disease
An observational study of older adults at elevated familial risk linked spinal fluid proteins to a rising Alzheimer’s marker over up to 12 years.An observational study of older adults at elevated familial risk linked spinal fluid proteins to a rising Alzheimer’s marker over up to 12 years.
In germline-deficient animals, KLF-1 was required for SKN-1 activation, oxidative stress resistance, and longevity without altering skn-1 transcript abundance.In germline-deficient animals, KLF-1 was required for SKN-1 activation, oxidative stress resistance, and longevity without altering skn-1 transcript abundance.