STAT3

Biomarker

8 papers4 findings

Humans2
Animals5
Cells1

Upstream

Relapsing-remitting multiple sclerosis

upin humans1

1 study

Relapsing-remitting multiple sclerosis increases STAT3 in humans.
“there was an increased percentage of pSTAT3 in these cells.”
Humansin CD4+CD25+FoxP3+ and CD8+CD25+FoxP3+ Tregsbloodfemales
Associations among IL-6 Signaling Molecules in Treg Populations in Patients with Relapsing-Remitting Multiple Sclerosis
Journal of integrative neuroscienceMay 26, 2025

More on Relapsing-remitting multiple sclerosis

Liver fibrosis

upin mice1

1 study

Liver fibrosis increases STAT3 in mice.
“STAT3 expression was upregulated and cellular senescence was increased in LF mice.”
Animalsin liver fibrosisliver
Identification of STAT3 as a biomarker for cellular senescence in liver fibrosis: A bioinformatics and experimental validation study
GenomicsJan 28, 2024

Associations

Major adverse limb events

downin humans1

1 study

STAT3 is associated with major adverse limb events in humans.
“in patients with limb ischemia we also observed a higher expression of circulating STAT3, associated with a lower rate of major adverse limb events (MALEs)”
Humansin patients with limb ischemia
Effects of STAT3 on aging-dependent neovascularization impairment following limb ischemia: from bedside to bench
AgingJun 13, 2022

Funding

1 grant since 2021

National Institute of Arthritis and Musculoskeletal and Skin DiseasesUS$1.2m

GP130/STAT3 signalling in articular cartilage development and regeneration
National Institute of Arthritis and Musculoskeletal and Skin DiseasesUniversity of Southern CaliforniaUS$71k2018–2024

Latest

73 in 12 months

Research SquareOct 16

Small RNA linked to death in younger people with COVID-19

In patients under 55, higher levels of a gene-regulating RNA were associated with death, with a reported odds ratio of 6.00.In patients under 55, higher levels of a gene-regulating RNA were associated with death, with a reported odds ratio of 6.00.

Preprint: study in peopleMechanisms

Paper

Translational Lung Cancer ResearchOct 14

Plasma proteomic profiles associated with low-dose computed tomography findings and incident lung cancer: a prospective pilot study

Cohort study of 188 peopleLung cancer

Paper

BiomaterialsOct 14

Chemically tailored lipids mediate solid-phase RNA programming of mineralized microenvironments

Experiments in human cellsInterventions

Paper

Journal of Inflammation ResearchOct 11

Hydroxygenkwanin Identified in Rehmanniae Radix Praeparata-Corni Fructus Ameliorates Postmenopausal Osteoporosis via Modulation of the AGE-RAGE Signaling Pathway

Experiments in ratsPostmenopausal osteoporosis

Paper

Biomedicine & PharmacotherapyOct 6

Sunitinib selectively killed senescent cells in the lab

A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals.A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals.

Experiments in human cellsInterventions

Paper

Cancer ResearchOct 5

Clearing senescent niche cells limits clonal hematopoiesis in mice

Mutant blood cells induced stromal senescence, while depleting senescent non-hematopoietic cells reduced clonal burden and delayed progression to myeloid neoplasia in…Mutant blood cells induced stromal senescence, while depleting senescent non-hematopoietic cells reduced clonal burden and delayed progression to myeloid neoplasia in mice.

Experiments in miceCellular senescence

Paper

Bioorganic ChemistryOct 1