Cellular senescence
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53Melissic acid reduces senescence in human stem cells via cAMP signaling
A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular…A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.
Altered cell communication impairs muscle recovery in older women after disuse
Single-nucleus sequencing reveals disrupted signaling between satellite cells and fibro-adipogenic progenitors during muscle regrowth in older…Single-nucleus sequencing reveals disrupted signaling between satellite cells and fibro-adipogenic progenitors during muscle regrowth in older females.
Peroxisomal stress drives cellular senescence by relocating SCAF1 to mitochondria
Processed SCAF1 halts mitochondrial ribosome assembly and induces senescence in human cell models following peroxisome import stress.Processed SCAF1 halts mitochondrial ribosome assembly and induces senescence in human cell models following peroxisome import stress.
Senescent prostate cancer cells drive stromal remodeling through TGF-beta signaling
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment…Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.
DNA methylation proxies of senescence markers track human disease and mortality
The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.The new blood-based tools estimate senescence gene activity to predict incident diseases, all-cause mortality, and clinical treatment responses.
Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial
The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence…The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.