IL-6 signalling
Pathway2 papersGO 0070102
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21Inflammatory burden links to racial disparities in heart failure
In a 16-year study of 6,785 adults, baseline inflammatory markers accounted for 57.5% of the Black-White log-hazard difference in incident heart…In a 16-year study of 6,785 adults, baseline inflammatory markers accounted for 57.5% of the Black-White log-hazard difference in incident heart failure.
Body fat and inflammation link ultraprocessed food to heart risk
In 6,531 adults, waist-to-height ratio mediated 44% and interleukin-6 mediated 13% of the association between ultraprocessed food intake and incident…In 6,531 adults, waist-to-height ratio mediated 44% and interleukin-6 mediated 13% of the association between ultraprocessed food intake and incident cardiovascular disease.
Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in…The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.
ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification…Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
Effects of an Adaptive Exercise Program on Inflammation After Spinal Cord Injury
Long-term human skin platform models chronic inflammation and senolytic treatments
The culture platform maintained native tissue architecture for four weeks, revealing treatment effects on aged donor tissue that emerged only after…The culture platform maintained native tissue architecture for four weeks, revealing treatment effects on aged donor tissue that emerged only after prolonged exposure.
Aging remodels mouse neutrophils across organs to drive inflammatory and senescence responses
Single-cell profiling reveals distinct neutrophil subsets that promote senescence in vascular and liver cells while altering bone marrow progenitor…Single-cell profiling reveals distinct neutrophil subsets that promote senescence in vascular and liver cells while altering bone marrow progenitor states.