Metabolic disorders
Disease10 papers
- Human trial2
- Humans2
- In silico1
Trial sponsors
Company1 trialPhase 3130 people
Company1 trial140 people
Jinnah Postgraduate Medical Centre
1 trialPhase 1116 people
Jinnah Sindh Medical University
1 trialPhase 1116 people
Funding
National Institute of Diabetes and Digestive and Kidney DiseasesUS$407.9k1 grant since 2023
Latest
95Immunosenescence in tumor progression: from synergistic mechanisms to therapeutic strategies
Higher CALLY index is causally linked to lower dementia risk
Mendelian randomization across more than 265,000 UK Biobank and FinnGen participants linked a higher CALLY score to reduced dementia risk but…Mendelian randomization across more than 265,000 UK Biobank and FinnGen participants linked a higher CALLY score to reduced dementia risk but increased sleep disorder risk.
Suppressing clk-1 restores lifespan and mitochondrial function in psd-1 deficient worms
Targeting ubiquinone biosynthesis counteracted reduced oxygen consumption and rescued lifespan loss caused by mitochondrial phosphatidylethanolamine…Targeting ubiquinone biosynthesis counteracted reduced oxygen consumption and rescued lifespan loss caused by mitochondrial phosphatidylethanolamine deficiency in Caenorhabditis elegans.
Inotodiol preserves muscle mass and function in aged mice
The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.