5 papers4 findings
SB000
downin human cells1
SB000 decreases senescence-associated gene expression in human cells.
“lowered single-cell transcriptomic age, and decreased senescence-associated gene expression.”
Cellsfibroblast
A single factor for safer cellular rejuvenation
bioRxiv (Cold Spring Harbor Laboratory)6 Jun 2025Preprint
Caloric restriction
downin mice1
Caloric restriction decreases senescence-associated gene expression in mice.
“A notable reduction in senescence-associated genes and restoration of circadian rhythm genes were observed, particularly in ventricles and white matter.”
Animalsbrain, particularly ventricles and white matter
Spatiotemporal profiling reveals the impact of caloric restriction on mammalian brain aging
bioRxiv : the preprint server for biology8 May 2025Preprint
Pdgf-ab / pdgf-bb
downin human cells1
Pdgf-ab / pdgf-bb decreases senescence-associated gene expression in human cells.
“while downregulating the expression of genes related to senescence associated phenotype, including oxidative stress, reactive oxygen species (ROS), and mitochondria dysfunction.”
Cellsderived from degenerated intervertebral discsrecombinant humannucleus pulposus and annulus fibrosus cells5 days
Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
bioRxiv : the preprint server for biology27 Mar 2025Preprint
Overall survival
upin humans1
Senescence-associated gene expression is associated with overall survival in humans.
“higher expression of senescence-associated genes was associated with improved survival in the overall lung cancer cohort and in lung adenocarcinoma”
Humanslung adenocarcinoma
Senescence-associated gene signatures predict survival in lung cancer: a multi-cohort analysis
GeroScience27 Sep 2025
In a laboratory experiment, chemically induced senescent human retinal cells showed increased mobility and altered binding of proteins that anchor DNA to the nuclear…In a laboratory experiment, chemically induced senescent human retinal cells showed increased mobility and altered binding of proteins that anchor DNA to the nuclear scaffold.