Pdgf-ab / pdgf-bb
1 paper3 findings
- 1 lab in 1 country
- Cells1
Outcomes
3Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Pdgf-ab / pdgf-bb decreases cellular senescence in human cells.
“mitigated the senescence progression through increased cell population in the S phase, reduced SA-β-Gal activity, and decreased expression of senescence related regulators”
Cellsirradiation-induced senescencerecombinant humannucleus pulposus cells
Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
bioRxiv : the preprint server for biology27 Mar 2025Preprint
PDGFRA expression
upin human cells1
1 study
PDGFRA expression
upin human cells1
Pdgf-ab / pdgf-bb increases PDGFRA expression in human cells.
“However, rhPDGF-AB/BB treatment increased PDGFRA expression”
Cellsirradiation-induced senescencerecombinant humannucleus pulposus cells
Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
bioRxiv : the preprint server for biology27 Mar 2025Preprint
Senescence-associated gene expression
downin human cells1
1 study
Senescence-associated gene expression
downin human cells1
Pdgf-ab / pdgf-bb decreases senescence-associated gene expression in human cells.
“while downregulating the expression of genes related to senescence associated phenotype, including oxidative stress, reactive oxygen species (ROS), and mitochondria dysfunction.”
Cellsderived from degenerated intervertebral discsrecombinant humannucleus pulposus and annulus fibrosus cells5 days
Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
bioRxiv : the preprint server for biology27 Mar 2025Preprint