Akkermansia muciniphila
InterventionPhase 24 papers8 findings
One study in male mice shows live Akkermansia muciniphila lowers CDKN1A and increases thermogenic gene expression in brown adipose tissue. One study in ovariectomised rats reports reduced bone loss and marrow adiposity expansion; a review describes improved cognition, inhibited inflammation and reduced human sarcopenia.
- Animals3
Outcomes
8Thermogenic gene expression
upin mice1Very low certainty
1 study
Thermogenic gene expression
upin mice1Very low certainty
Akkermansia muciniphila increases thermogenic gene expression in mice.
Animalslivebrown adipose tissue30 daysmales
Age-associated Akkermansia muciniphila decline links to brown adipose tissue aging: AKK supplementation improves BAT metabolic function · Beneficial microbes · 17 Sep 2026
CDKN1A
downin mice1Very low certainty
1 study
CDKN1A
downin mice1Very low certainty
Akkermansia muciniphila decreases CDKN1A in mice.
Animalslivebrown adipose tissue30 daysmales
Age-associated Akkermansia muciniphila decline links to brown adipose tissue aging: AKK supplementation improves BAT metabolic function · Beneficial microbes · 17 Sep 2026
Pathological bone marrow adiposity expansion
downin rats1Very low certainty
1 study
Pathological bone marrow adiposity expansion
downin rats1Very low certainty
Akkermansia muciniphila decreases pathological bone marrow adiposity expansion in rats.
Animalsin ovariectomized rats
Akkermansia muciniphila alleviates osteoporosis by suppressing bone marrow adiposity through the gut microbiota-UDCA-TGR5 axis · Life sciences · 13 Sep 2026
Bone loss
downin rats1Very low certainty
1 study
Bone loss
downin rats1Very low certainty
Akkermansia muciniphila decreases bone loss in rats.
Animalsin ovariectomized rats
Akkermansia muciniphila alleviates osteoporosis by suppressing bone marrow adiposity through the gut microbiota-UDCA-TGR5 axis · Life sciences · 13 Sep 2026
Inflammation
downin reviews1
1 study
Inflammation
downin reviews1
Akkermansia muciniphila inhibits inflammation.
Review
Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging · Aging cell · 1 Sep 2026
Sarcopenia
downin humans1
1 study
Sarcopenia
downin humans1
Akkermansia muciniphila decreases sarcopenia in humans.
Review
Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging · Aging cell · 1 Sep 2026
Cognitive function
upin reviews1
1 study
Cognitive function
upin reviews1
Akkermansia muciniphila improves cognitive function.
Review
Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging · Aging cell · 1 Sep 2026
M2 macrophage polarization
upin mice1Very low certainty
1 study
M2 macrophage polarization
upin mice1Very low certainty
Akkermansia muciniphila induces M2 macrophage polarization in mice.
Animalssenescent niche
Single-cell transcriptomic-driven design of cascade-responsive hydrogel with bioinspired nanocellular pacemaker for aged bone regeneration · Biomaterials · 25 Aug 2026