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SB000

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 2 countries
  • 4 of 4 findings with company ties
  • Cells1

Outcomes

4

Cellular rejuvenation

upin human cells1

1 study

  1. SB000 induces cellular rejuvenation in human cells.

    “SB000 rejuvenation generalises to keratinocytes, cells from another germ layer, with potency matching or surpassing OSK(M).”

    Cellscompared with OSK(M)keratinocyte

    A single factor for safer cellular rejuvenation

    bioRxiv (Cold Spring Harbor Laboratory)6 Jun 2025Preprint

Fibroblast identity

no changein human cells1

1 study

  1. SB000 has no effect on fibroblast identity in human cells.

    “In contrast to OSK(M), SB000 treatment maintains transcriptomic and functional measures of fibroblast identity without the activation of pluripotency.”

    Cellsfibroblast

    A single factor for safer cellular rejuvenation

    bioRxiv (Cold Spring Harbor Laboratory)6 Jun 2025Preprint

Senescence-associated gene expression

downin human cells1

1 study

  1. SB000 decreases senescence-associated gene expression in human cells.

    “lowered single-cell transcriptomic age, and decreased senescence-associated gene expression.”

    Cellsfibroblast

    A single factor for safer cellular rejuvenation

    bioRxiv (Cold Spring Harbor Laboratory)6 Jun 2025Preprint

More on Senescence-associated gene expression

Epigenetic clock age

downin human cells1

1 study

  1. SB000 decreases epigenetic clock age in human cells.

    “SB000 drives multi-omic rejuvenation in human fibroblasts, as evidenced by substantial reversal of numerous epigenetic clocks”

    Cellsfibroblast

    A single factor for safer cellular rejuvenation

    bioRxiv (Cold Spring Harbor Laboratory)6 Jun 2025Preprint

More on Epigenetic clock age

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