Researchers identified three vessel states across disease severity by analysing 11,409 vessel fragments from post-mortem brain tissue from 20 cases.Researchers identified three vessel states across disease severity by analysing 11,409 vessel fragments from post-mortem brain tissue from 20 cases.
Cross-sectional study of 20 brain donors across cerebral small vessel disease severitiesMechanisms
Limit: Controls were not age-matched, so ageing could explain disease-associated vascular differences
An analysis of three published datasets, validated in 15 human skin samples, identified an aging-linked subgroup of cells that support small blood vessels.An analysis of three published datasets, validated in 15 human skin samples, identified an aging-linked subgroup of cells that support small blood vessels.
In 45 patients with heart failure with preserved ejection fraction, diet and exercise partially reversed altered gene activity and DNA packaging in muscle.In 45 patients with heart failure with preserved ejection fraction, diet and exercise partially reversed altered gene activity and DNA packaging in muscle.
Single-cell analysis of four aged human donor eyes revealed complement membrane attack complexes concentrated primarily on pericytes, smooth muscle cells, and…Single-cell analysis of four aged human donor eyes revealed complement membrane attack complexes concentrated primarily on pericytes, smooth muscle cells, and macrophages.
Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.Targeting this pathway curbs mitochondrial oxidative stress and pericyte activation to partially restore auditory function in mouse models.