5 papers
National Institute on AgingUS$6.1mNational Institute of Neurological Disorders and StrokeUS$295k
Role Of Apolipoprotein E In Maintaining the Blood Brain Barrier Integrity
National Institute of Neurological Disorders and StrokeCalifornia State University Long BeachUS$147.5k2024–2028
Apolipoprotein E glycosylation and its role in Alzheimer's disease pathogenesis
National Institute on AgingUniversity of VirginiaUS$538.9k2024–2027
National Institute on AgingNathan S. Kline Institute for Psych ResUS$2.5m2024–2027
National Institute on AgingOregon Health & Science UniversityUS$192.5k2023–2026
A Therapeutic Role for Apolipoprotein-E in the Germ Theory of Alzheimer's Dementia
National Institute on AgingRegennovaUS$500k2023–2025
An observational study of 110 adults aged 65–88 with depression found separate, additive links to amyloid, a protein, only in carriers of a genetic variant.An observational study of 110 adults aged 65–88 with depression found separate, additive links to amyloid, a protein, only in carriers of a genetic variant.
Alzheimer’s tissue changes were associated with 9.09-point higher dementia ratings in unfavourable social profiles, versus 6.39-point higher ratings in favourable…Alzheimer’s tissue changes were associated with 9.09-point higher dementia ratings in unfavourable social profiles, versus 6.39-point higher ratings in favourable profiles.
In 5,774 adults followed for an average of 4.7 years, carrying two APOE ε4 alleles and female sex were linked to faster hippocampal shrinkage.In 5,774 adults followed for an average of 4.7 years, carrying two APOE ε4 alleles and female sex were linked to faster hippocampal shrinkage.
In two observational cohorts, genetic scores were linked to faster progression to Alzheimer’s disease, with hazard ratios, a measure of risk over time, of 1.25 to 2.02.In two observational cohorts, genetic scores were linked to faster progression to Alzheimer’s disease, with hazard ratios, a measure of risk over time, of 1.25 to 2.02.