Vitality

Biomarker

2 papers

  • Humans2

Funding

1 grant since 2025

National Cancer InstituteUS$1.2m

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The Lancet Healthy Longevity

Adults 50-plus born later had higher capacity in 10 European countries

Later birth years were linked to higher capacity at entry than earlier birth years, with a model coefficient—a measure of association—of 0.797.Later birth years were linked to higher capacity at entry than earlier birth years, with a model coefficient—a measure of association—of 0.797.

Cohort study of 80,105 peoplePopulations
The Journals of Gerontology, Series A

Intrinsic capacity declines in community-dwelling older US adults

In 5,834 community-dwelling older Americans, intrinsic capacity scores showed progressive age-related decline and were lower in females than in males.In 5,834 community-dwelling older Americans, intrinsic capacity scores showed progressive age-related decline and were lower in females than in males.

Cross-sectional study of 5,834 peopleBiomarkers
Journal of Global Health

Higher education than parents is linked to healthier aging

In an observational study of over 100,000 older adults across five countries, upward educational mobility was linked to higher overall physical and mental capacity.In an observational study of over 100,000 older adults across five countries, upward educational mobility was linked to higher overall physical and mental capacity.

Cohort study of 100,362 peoplePopulations
Journal of Cellular Physiology

Sestrin1 protects aging livers and aids exercise in mice

In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.In aged mice, lacking Sestrin1 worsened liver cell senescence and fat buildup, and the protein proved indispensable for the liver benefits of exercise.

Experiments in miceExercise
Psychological Medicine

More functional deficits linked to depression and anxiety

Scores of four or more versus zero were linked to higher risks of depression and anxiety, with hazard ratios of 3.96 and 3.03, respectively.Scores of four or more versus zero were linked to higher risks of depression and anxiety, with hazard ratios of 3.96 and 3.03, respectively.

Cohort study of 212,033 peopleAnxiety