Charlson Comorbidity Index
Biomarker3 papers5 findings
- Humans3
Effects
1Hospital-associated disability
no changein humans1OR 0.98
1 study
Hospital-associated disability
no changein humans1OR 0.98
Charlson Comorbidity Index has no effect on hospital-associated disability in humans (OR 0.98, 95% CI 0.90-1.06).
Humansin frail hospitalized older adults (CFS ≥5)n = 1,299
Comorbidity predicts disability only in nonfrail older patients · Journal of the American Medical Directors Association · 30 Sep 2026
Associations
3Hospital-associated disability
no changein humans1upin humans1OR 1.11–1.44
1 study
Hospital-associated disability
no changein humans1upin humans1OR 1.11–1.44
Charlson Comorbidity Index is associated with hospital-associated disability in humans (OR 1.11, 95% CI 0.91-1.35).
Humansin mildly frail hospitalized older adults (CFS 4)n = 1,299
Comorbidity predicts disability only in nonfrail older patients · Journal of the American Medical Directors Association · 30 Sep 2026
Charlson Comorbidity Index raises the risk of hospital-associated disability in humans (OR 1.44, 95% CI 1.20-1.73).
Humansin nonfrail hospitalized older adults (CFS ≤3)n = 1,299
Comorbidity predicts disability only in nonfrail older patients · Journal of the American Medical Directors Association · 30 Sep 2026
1-year mortality
upin humans1
1 study
1-year mortality
upin humans1
Charlson Comorbidity Index is associated with 1-year mortality in humans (adjusted odds ratio 2.55, 95% confidence interval 1.43-7.21).
Humansfragility fracture of the pelvis1-yearn = 46
Association between the updated Charlson comorbidity index and 1-year mortality after fragility fracture of the pelvis: A prospective observational study · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 29 Sep 2026
Non-home discharge
upin humans1
1 study
Non-home discharge
upin humans1
Charlson Comorbidity Index raises the risk of non-home discharge in humans.
Humanshead and neck free flap surgery
Radiologic Sarcopenia and Charlson Comorbidity Index in the Head and Neck Free Flap Population · Laryngoscope investigative otolaryngology · 28 Sep 2026
Latest
6Machine learning stratifies disability risk in older adults
An XGBoost model reached an AUC of 0.782 in an external cohort of 2,066 older adults to predict basic activities of daily living disability.An XGBoost model reached an AUC of 0.782 in an external cohort of 2,066 older adults to predict basic activities of daily living disability.
AGA Clinical Practice Update on Surveillance of Pancreatic Cystic Lesions and Hepatocellular Carcinoma in Older Adults: Expert Review
Comorbidity predicts disability only in nonfrail older patients
Higher comorbidity scores raised disability odds in nonfrail patients (OR 1.44) but not in frail patients (OR 0.98) across 1,299 hospitalized older…Higher comorbidity scores raised disability odds in nonfrail patients (OR 1.44) but not in frail patients (OR 0.98) across 1,299 hospitalized older adults.