Adverse adulthood experiences

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funders: Beijing Municipal Health Commission and 6 more

Humans2

Outcomes

Intrinsic capacity

no changein humans1

1 study

Adverse adulthood experiences have no effect on intrinsic capacity in humans.
“whereas AAEs showed no significant association with IC.”
Humans
Adverse childhood and adult experiences, intrinsic capacity decline, and subsequent physical-psychological-cognitive multimorbidity: a prospective cohort study from China
The journal of nutrition, health & aging28 Mar 2026

Associations

Physical-psychological-cognitive multimorbidity

upin humans1HR 1.18

1 study

Adverse adulthood experiences raise the risk of physical-psychological-cognitive multimorbidity in humans (HR 1.18 (95% CI 1.03-1.34)).
“while each additional AAE increased risk by 18% (HR 1.18; 95% CI 1.03-1.34).”
Humans
Adverse childhood and adult experiences, intrinsic capacity decline, and subsequent physical-psychological-cognitive multimorbidity: a prospective cohort study from China
The journal of nutrition, health & aging28 Mar 2026

More on Physical-psychological-cognitive multimorbidity

Parkinson's disease

no changein humans1HR 1.02

1 study

Adverse adulthood experiences are associated with Parkinson's disease in humans (HR 1.02, 95% CI 0.95-1.10).
“and PD (1.02, 0.95-1.10), though the latter was not statistically significant.”
Humans
Adverse experiences in childhood and young adulthood, genetic susceptibility, and neurodegenerative disease incidence: a lifespan analysis
European journal of psychotraumatology17 Dec 2025