2 papers
Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.Transplanting ovaries between younger and older mice shifted molecular age estimates in both directions, but the changes remained partial.
An experiment spanning 16 combinations of age, sex and infection stage also found persistent inflammatory responses in older male mice at later stages.An experiment spanning 16 combinations of age, sex and infection stage also found persistent inflammatory responses in older male mice at later stages.
In aged mice, treatment after injury cleared inflammatory cells faster, expanded muscle-forming cells, and trended toward improved muscle contraction.In aged mice, treatment after injury cleared inflammatory cells faster, expanded muscle-forming cells, and trended toward improved muscle contraction.
A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.A multi-omic analysis shows that defective luteal resolution and CHK2-driven inflammation drive ovarian aging, but drug inhibition restores oocyte maturation.
In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with aggravated chronic cardiac…In 2- and 18-month-old mice of both sexes, elevated interferon-gamma showed little acute impact after myocardial infarction but tracked with aggravated chronic cardiac remodeling.