GLELR
1 paper4 findings
- 1 lab in 1 country
- Funders: Bundesministerium für Bildung und Forschung and 2 more
- Cells1
Effects
2Inflammation
downin human cells1downin mouse cells1
1 study
Inflammation
downin human cells1downin mouse cells1
GLELR decreases inflammation in human cells.
“where its loss similarly promoted inflammatory gene expression and phagocytosis.”
Cellsloss of GLELRiPSC-derived microglia
lncRNA Glelr modulates microglia inflammatory programs in association with PU.1
Neurobiology of disease25 Mar 2026
GLELR decreases inflammation in mouse cells.
“Knockdown of Glelr in primary microglia led to enhanced expression of pro-inflammatory cytokines, including TNFα”
Cellsknockdown of Glelrmicroglia
lncRNA Glelr modulates microglia inflammatory programs in association with PU.1
Neurobiology of disease25 Mar 2026
Phagocytic activity
downin mouse cells1
1 study
Phagocytic activity
downin mouse cells1
GLELR decreases phagocytic activity in mouse cells.
“Knockdown of Glelr in primary microglia led to enhanced expression of pro-inflammatory cytokines, including TNFα, and increased phagocytic activity.”
Cellsknockdown of Glelrmicroglia
lncRNA Glelr modulates microglia inflammatory programs in association with PU.1
Neurobiology of disease25 Mar 2026
Associations
1Alzheimer's disease
downin human cells1
1 study
Alzheimer's disease
downin human cells1
Alzheimer's disease is associated with GLELR in human cells.
“GLELR expression was significantly reduced in postmortem Alzheimer's disease (AD) brains”
Cellsin postmortem brainsbrain
lncRNA Glelr modulates microglia inflammatory programs in association with PU.1
Neurobiology of disease25 Mar 2026