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INTERLEUKIN-1 alpha

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Agencia Estatal de Investigación and 2 more
  • Animals1

Outcomes

3

IL-6 secretion

upin human cells1

1 study

  1. INTERLEUKIN-1 alpha increases IL-6 secretion in human cells.

    “interleukin 1α (IL-1α) in dividing and senescent fibroblasts, accompanied by an increase in IL-6 secretion.”

    Cellsdividing and senescent fibroblastsfibroblast

    Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing

    Frontiers in aging4 Jun 2025

More on IL-6 secretion

ANKH expression

downin human cells1

1 study

  1. INTERLEUKIN-1 alpha decreases ANKH expression in human cells.

    “EC and ANKH were inhibited by interleukin 1α (IL-1α) in dividing and senescent fibroblasts”

    Cellsdividing and senescent fibroblastsfibroblast

    Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing

    Frontiers in aging4 Jun 2025

More on ANKH expression

Extracellular citrate

downin human cells1

1 study

  1. INTERLEUKIN-1 alpha decreases extracellular citrate in human cells.

    “EC and ANKH were inhibited by interleukin 1α (IL-1α) in dividing and senescent fibroblasts”

    Cellsdividing and senescent fibroblastsfibroblast

    Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing

    Frontiers in aging4 Jun 2025

More on Extracellular citrate

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